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Anti-Bodies Against Platelets - Necessary?

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14 years 9 months ago #10577 by DelnStyle
Anti-Bodies Against Platelets - Necessary? was created by DelnStyle
Hello all:

I'm slightly confused. In order to have ITP, does that mean you NEED to have antibodies against platelets?
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 9 months ago #10587 by Sandi
Replied by Sandi on topic Re: Anti-Bodies Against Platelets - Necessary?
No. Antibodies are undetectable in some individuals.

"Autoantibodies against platelet antigens are considered the diagnostic hallmark of ITP. In some patients, antibodies recognize antigens derived from a single glycoprotein; whereas in others, antibodies recognize multiple glycoproteins.1 Opsonization by antibody accelerates platelet clearance but can also alter platelet function and interfere with platelet production. Curiously, platelet antibodies are only detected in approximately 60% of patients. Failure to detect antibodies might reflect limited test sensitivity, undetected antigens, or additional mechanisms of platelet loss. Potential mechanisms that do not implicate B cells must be reconciled with the more than 80% initial response rate to intravenous immunoglobulin (IVIG) and splenectomy."

bloodjournal.hematologylibrary.org/cgi/content/full/113/26/6511?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=ITP+immune&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
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14 years 9 months ago #10619 by DelnStyle
Replied by DelnStyle on topic Re: Anti-Bodies Against Platelets - Necessary?
So, if there are no anti-bodies against platelets, does this preclude the use of WinRHO as a treatment option? Because doesn't the WinRHO sort of alter the antibodies to latch to red blood cells instead of platelets?
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 9 months ago #10651 by Sandi
Replied by Sandi on topic Re: Anti-Bodies Against Platelets - Necessary?
Yes, that is what Win-Rho does, but if you read what I posted (hard to grasp, I know), it states that there are reasons why antibodies are not detectable in some people. One of those reasons is that the antibodies may not be detectable because they are not 'known'. Win-Rho can work against an antibody that hasn't been discovered yet.

There are too many "ifs". The only way to know if it works is to try it. I had a high presence of detectable antibodies and Win-Rho didn't raise my counts at all. You never know.
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14 years 9 months ago #10696 by lili
Replied by lili on topic Re: Anti-Bodies Against Platelets - Necessary?
Actually, Win-Rho contains antibodies that bind to the red blood cells, not the platelets. The spleen is then kept busy destroying the red blood cells and can't get to the platelets. That's why it causes anemia and why you're supposed to have a spleen for Win-Rho to work. This is also why you have to be Rh+. I think it binds to the Rh+ protein on the red blood cells.

There are many, many antibodies, but they're usually specific to one thing. So for example if you have strep throat, you will be making antibodies that bind to different parts of the strep germ. You're not supposed to be making antibodies to yourself, but the problem in ITP and other autoimmune diseases is that somehow the immune system gets confused and starts making antibodies to our own bodies.

It's a very complex system.

Lily
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 9 months ago #10705 by Sandi
Replied by Sandi on topic Re: Anti-Bodies Against Platelets - Necessary?
You are correct about that, Lily. I was up way too late! At any rate, anti-platelet antibodies do not have to be detected for Win-Rho to work.
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