Platelet Count, Creatinine levels, related to Celiac?

I've been taking Promacta for the past 9 months. As most of you who take it know, besides the Complete Blood Count (aka CBC) test, you also get a Comprehensive Metabolic Panel (aka CMP) test as well. This is to check if the liver is having problems metabolizing the Promacta. Elevated AST or ALT values are indicative of a problem. Anyhow, these regular CMP tests have popped up an issue. An issue which seems to be quite relevant and helpful, for me at least. See if it is relevant for you with a simple scan of old CMP tests - especially if there is a suspicion of gluten sensitivity.

On most of my CMP tests the Creatinine level has been within normal range. On the high side, but within range. In a few tests, they have jumped out to an out of range high. In my latest test this out of range high happened again. Also on that test, my platelet count was a bit lower than expected - as described here.

Following the lead of some other PDSA members who closely scrutinizing their lab results, I decided to see if I could do a little research and see what I could come up with. I wondered if Celiac and gluten reactions could be linked to Creatinine levels. But how?

First I found out that measuring Creatinine level is used as an indicator to Kidney function in the CMP test. The higher the blood Creatinine level, the less it is being removed by the Kidneys. Thus poor function. On the surface, high out of range Creatinine looks like Chronic Kidney Disease. Thus my doctor has marked CKD on my paper work! Blah. Next, I reread the Wiki article on Celiac. That a Celiac 'flair' is a release of IgA antibodies into the blood stream. A release for the antibodies to find the evil gluten in the gut and destroy it. Then I stumbled across a Celiac blog which talked about how 'IgA Nephropathy' is an issue for Celiacs. That the IgA antibodies in the blood can deposit in the kidney and cause reduction in kidney function. When/If the IgA clears, kidney function returns.

So there it is. A Celiac flair causes IgA to be released. Some IgA deposits in the kidneys causing reduced function. The reduced function results in elevated Creatinine levels in one's blood test. It's simple my dear Watson.

Now, can I leverage the relation for platelets? I looked back at old tests and compared platelet counts when Creatinine was normal and when it was high. Check if a Celiac flair (high Creatinine) had a affect on counts. Low and behold, it did. Every time there was a flair my counts were unexpectedly lower by 15 to 30 points. Nice.

Hope you find this useful.

So then my question would be....have you ever been tested for Celiac's?

I've had many CMP's over the years and my creatinine has always been low normal, even when my counts were low. I was tested for Celiac's and it was negative. I do believe that I have a gluten sensitivity though based on how I felt when I stopped eating it.

I think gluten allergies or sensitivities could potentially cause any health problem. I used to think that people who talked about leaky gut were nuts. I've since totally changed my mind.

Sandi, they want you to eat gluten for like 6 weeks for that test. Since I have the obvious link between eating gluten and my forehead breaking out, don't find the need to do it. If I wanted to take Dapsone for it then I would take the test. Dapsone stops the symptoms but does nothing to help or speed recovery.

Your mention of glyphosate (RoundUp) in foods on another thread makes sense to me. Years ago I eliminated corn from my diet because of a mild stomach pain issue. I thought I had leaky gut. Eliminating corn seemed to help a little. In hindsight I now know it was hPylori that caused the stomach issue. It too causes leaky gut. Now that hPylori has been eradicated, I have zero stomach issues. LOL, I still avoid corn though.

As you mention, gluten sensitivity could be it. Seems like those that do look into it notice some effect. I remember last year, I decided to eat a hamburger (with wheat/gluten bun) and see if I got a dermatitis reaction on my forehead. I got the dermatitis alright. But what amazed me was I felt like I had eaten a brick. A large brick. It was so heavy feeling. Didn't want to eat the rest of the day it was so heavy. I think wheat has become so pervasive in foods, especially fast foods, because it is so cheap and makes you feel so full. LOL, how long is the bread isle, and how long is the corn chip isle, in your grocery store?

Edit.
Oh forgot to mention. As I understand corn is now universally 'GMO corn'. It's been genetically modified. Whatever is in RoundUp which kills weeds has been inserted into the genes of corn. Oh boy, yum! Don't know where one can buy organic corn. Easiest to just avoid it.

We have local farmers that sell corn on the side of the roads. I don't know if it is GMO or not, but that's what I buy. Monsanto is buying out all of the farmers and there is cross-contamination going on. It's a shame that 'real' nutritious food is disappearing. People don't understand what GMO really is. They think it's a hybrid.

Ran across this article from 1987 about treating IgA Nephropathy with Danazol.
"Clinical Effect of Danazol in Patients with IgA Nephropathy"
www.jstage.jst.go.jp/article/internalmedicine1962/26/2/26_2_162/_pdf

Apparently Danazol (aka Danocrine) suppresses not just IgG antibodies but IgM and IgA antibody levels as well. Hence Danazol is good for both ITP and IgA Nephropathy. Typical treatments were 200 to 300mg of Danazol for 20 weeks in the study. The author suggests that 'solubilization' of the IgA deposits allows improved kidney function even after treatment is discontinued.