Massachusetts General Hospital in Boston is conducting a longitudinal observational study to evaluate for the prevalence and extent of cognitive dysfunction in adults with persistent and chronic ITP. Following enrollment, subjects will complete neurocognitive testing and will complete surveys for patient-reported outcomes of quality of life, fatigue, self-reported cognitive function, and depression. Background characteristics and relevant clinical history will be obtained through an enrollment survey and chart review. The primary aim of the study is to describe the prevalence and extent of cognitive impairment in ITP and explore associated risk factors. This study will also assess the feasibility of longitudinal cognitive testing in patients with ITP and describe any observed changes in cognition over time.
This study is open to individuals with confirmed persistent or chronic ITP who are over the age of 18 years, defined as having a platelet count less than 50 x 109/L on two occasions in the preceding 3 to 12 months or greater with a documented response to at least 1 prior ITP-directed therapy. Participants must also be able to follow instructions in English.
USA
Actively Recruiting