Platlet Circulation Theory Of Remission

I have been thinking about the pathways of remission and how people achieve them.
Let me define remission as 30k+ platelets with no intervention.

My theory states that no matter what medication or surgery you undergo-
- if one of the treatments create enough platelets then you go into a positive feedback loop which creates more platelets.
Then you get into equilibrium.
- Splenectomy works the same way, if you undergo surgery and there is rush of platelets then that provides positive feedback loop which creates more platelets.
This is why you see very varied individual responses to each treatment and no logic in remission.

I do believe exercise especially mix of cardio and strength training helps in remission achieve faster.
So a combination of treatment which works + combined with exercise will help in remission.

Jay, are you aware that Thrombopoietin <-> platelet production interaction is a 'negative feedback loop'? Just off hand a theory like this would have to include the TPO aspect. That is, not a positive feedback loop, but a change of the existing negative one. Yes?
Wiki describes the TPO feedback loop briefly. Google for more.
en.wikipedia.org/wiki/Thrombopoietin#Function_and_regulation

Hi Hal,
I dont think Thrombopoietin has much effect here, I did get sucked into TPO effects initially but my WBC responses put that to rest.

Answer lies more in the Treg cells and cytokine signalling side with inflammation playing a major role.
What I believe is happening is as IL-10 slowly increases and up- regulates Treg cells.
More Treg cells go up we see less killer t cells.
So as time goes on Treg and Killer T balances out with platelets going up or atleast finds an equilibrium.


Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
www.ncbi.nlm.nih.gov/pmc/articles/PMC3088485/

hey
Whether you are right or wrong , Im going to start exercising after reading this ! I used to exercise a lot (both cardio and strength) but after onset of itp I stop . now , Im going to start it again