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Wbc

  • Kelirae24
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  • I'm 31 years old and a mom to two awesome little boys, I was diagnosed with itp when I was 17 years old. With no treatment my counts are 0-5 I am currently on nplate and I had a splenectomy in 2004
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10 years 2 months ago #53297 by Kelirae24
Wbc was created by Kelirae24
So at least once a month my wbc is in the 14-15 range and I don't feel that good or sometimes I feel fine my dr told me it's because I don't have a spleen my numbers fluctuate. Has anyone heard of this? Or have the same problem?

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  • Kelirae24
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  • I'm 31 years old and a mom to two awesome little boys, I was diagnosed with itp when I was 17 years old. With no treatment my counts are 0-5 I am currently on nplate and I had a splenectomy in 2004
More
10 years 2 months ago #53298 by Kelirae24
Replied by Kelirae24 on topic Wbc
Sometimes I feel like he just doesn't want to look into anything

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10 years 2 months ago #53299 by Aoi
Replied by Aoi on topic Wbc
I have seen something similar with my mother. She had her spleen out last year as a part of cancer treatment and since then has had mildly elevated WBC counts from tiem to time. It seems that the reaction of doctors to an elevated WBC count after splenectomy varies depending on the reason for removing the spleen. A literature search in Pubmed using the keyphrase "wbc count after splenectomy" produces some interesting articles on the subject.

Also bear in mind that WBC values rise during and after infection. In other words, you may be feeling bad due to mild infection, which in turn could raise your WBC. I hope you can convince your doctor to explain what is going on with you. There may be nothing to look into here, but he should tell you why the elevated WBC is not clinically significant.

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10 years 2 months ago - 10 years 2 months ago #53307 by Rob16
Replied by Rob16 on topic Wbc

www.aafp.org/afp/2000/1101/p2053.html
Splenectomy causes a transient leukocytosis [elevated WBC] that lasts for weeks to months.

archsurg.jamanetwork.com/article.aspx?articleid=212767
Leukocytosis After Posttraumatic Splenectomy - A Physiologic Event or Sign of Sepsis?
Comments:
The phenomenon of temporary leukocytosis following splenectomy has been well known for many decades as a physiologic response to the removal of the spleen.8 Ironically, leukocytosis is also a prominent finding of postoperative sepsis, a common and much feared complication of splenectomy. Therefore, confusion exists as to whether postsplenectomy leukocytosis should be considered a normal finding or a warning sign mandating treatment.

Previous reports have shown a difference in the magnitude and persistence of leukocytosis between patients with and without sepsis after splenectomy. Sekikawa and Shatney3 found that from the 6th to the 10th postoperative day, most patients with sepsis had leukocyte counts greater than 20 × 103/µL vs patients without sepsis with counts less than 17 × 103/µL. Similarly, Rutherford et al10 suggested that a leukocyte count greater than 20 × 103/µL after the 10th postoperative day should initiate a vigorous search for infection. One could argue that the significance of leukocytosis should be determined much earlier than the 10th postoperative day; by then, sepsis is usually overt and the chance for early treatment is lost.

In our study, we tried to determine the earliest postoperative day that a specific WBC predicts the development of sepsis. A WBC greater than 15 × 103/µL at and after the fifth postoperative day emerged as a reliable predictor of sepsis. Our findings are in agreement with those of Horowitz et al,9 who found that following posttraumatic splenectomy, 18 infected patients had a WBC greater than 16 × 103/µL compared with 24 noninfected patients with a WBC less than 16 × 103/µL.


Searched using Google Scholar scholar.google.com search terms: elevated leukocyte splenectomy

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 2 months ago - 10 years 2 months ago #53308 by Sandi
Replied by Sandi on topic Wbc
Keli:

I wouldn't worry about it. Your doctor will know if it is a problem. Counts can be off on the reference range and still be okay, like platelets. You know that 80k is not normal on the reference range, but you also know that it's not a serious problem. Medications such as steroids can also cause the white count to go up.

More than likely, it's because you don't have a spleen and your body is compensating it's immune response with higher white counts. Mine are always low and the rest of the CBC is all over the place. I once had lymphocytes so high they were flagged as critical. It was monitored for a few weeks and eventually went back down.

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