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News Article: Platelet formation mechanism

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10 years 11 months ago #48723 by delta809
News Article: Platelet formation mechanism was created by delta809
This article was from January this year so assuming this may not be new to everyone. I searched and did not find it posted so I thought I would post.

Scientists discover a new blood platelet formation mechanism

Summary:
A new cellular mechanism, called the endocycle, encourages the formation of platelets, the cells needed to coagulate blood. In mouse models, endocycles can help to control thrombocytopenia, a disease caused by a deficit in platelet production that causes heavy haemorrhaging. The new process could act as an alternative source of platelets when the normal mechanisms fail.

www.sciencedaily.com/releases/2015/01/150126124727.htm

www.ncbi.nlm.nih.gov/pubmed/25625205

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 11 months ago #48725 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
Hmmm. I wonder if it also applies to ITP?

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 11 months ago #48735 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Me too Sandy as deficient platelet production is only one possible cause of ITP. My ITP for example is caused by excessive platelet destruction

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 11 months ago #48737 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
Curious, how do you know that?

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 11 months ago - 10 years 11 months ago #48752 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Indium scan showed splenic destruction of platelets & bone marrow biopsy proved platelet production fine..in fact on overtime producing extra platelets attempting to make up for deficit. Hence my opting to enrol on the fostamatininb trial.

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 11 months ago - 10 years 11 months ago #48754 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
pdsa.org/forum-sp-534/6-general-itp-discussion/11698-bone-marrow-biopsy-and-production-answers.html

I thought there was some new way to discover production vs destruction.

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 11 months ago #48756 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
I read my own biopsy results & watched my indium scan therefore know how rapidly my platelets are being destroyed. I believe them

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  • EmilyK
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  • Diagnosed jan 2015 at age 50 with 13,000 platelets.
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10 years 11 months ago #48757 by EmilyK
Replied by EmilyK on topic News Article: Platelet formation mechanism
Mrs B
How are things going on the trial? I think you ow get the real drug, correct?

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 11 months ago #48763 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
I believe the Indium as far as destruction, I'm not questioning that. It's just that the bone marrow biopsy results do not prove that production is adequate even though that is a common belief. We've all shown adequate production results based on the number of megakaryocytes, but it is a misconception discovered in the past few years. Few doctors know this. Dr. Provan does, he's a good one to ask.

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 11 months ago - 10 years 11 months ago #48766 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Cheers for that Sandi I will discuss with my consultant

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 11 months ago #48767 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Too soon to Say Emily I've only been on it 6 days. Have a repeat count on June 1st
The following user(s) said Thank You: EmilyK

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