njppp.com/fulltext/28-1486322158.pdf
People want to know why Carica papaya leaf extract works. Well here is the reason, or two of the reasons:
"The active ingredients of CPLE are known to upregulate ALOX 12 and PTAFR genes which in turn are responsible for increased production of megakaryocytes and its conversion into platelets. Clinical evidence shows that CPLE increases ALOX 12 activity 15-fold and PTAFR activity 13.42-fold which is responsible for increased platelet production in patients with dengue fever and dengue hemorrhagic fever.[11] Hence, this study was planned to explore the possibility of using CPLE in the treatment of CIT."
When you increase important platelet activity 15 fold for one, and 13.42 fold for another important activity, there you go.
As always, depends on the dose. If you don't use enough, then it won't even help. But it can knock the count right out of the park, too. Its a sensitive thing, and I still don't have it under control, yet. Wish me luck.
I will say that in this study, they did use a large amount. They used 3300 mg per day (for 7 days). My favorite for getting platelets up quick is 2000 mg per day for 4 days straight. So be careful. You seriously don't want to go overboard, so you need consistent blood tests to do this. Of course in this study, you would think that some of the patients may have gone overboard...
