I use to take Sinequan (Doxipin) a few times a week to help me sleep (works like Benedryl), and I never had to worry about sleep that much. Eventually, I would relax enough to go to sleep on the days I took the Sinequan. But, before I had my last platelet crash last year, I started getting a rash and swelling on my lips from this medication. Once I stopped it, the rash and swelling went away. I think it also drops my platelets--so I don't dare take it any longer (besides--my lips would get really large and looked quite funny). So, it's back to the spare bedroom on really bad days (somehow I associate it with being more calm).