Grapefruit Juice and Cyclosporine

I just found a couple of articles combining grapefruit juice with cyclosporine, which is known to be a no-no to take grapefruit juice with cyclosporine. They realize that the drug will increase, so they use the grapefruit juice to lower the dose and the theoretical side effects. Interesting! First link talks about cyclosporine and grapefruit juice towards the bottom, so read on. 

haematologica.org/article/view/4931#:~:text=However%2C%20although%20there%20is%20no,an%20increased%20risk%20of%20bleeding .

ashpublications.org/blood/article/91/1/362/260351/Clinical-Interaction-Between-Grapefruit-Juice-and

Whether its safe, I don't know, say for the kidneys, but may be. Like maybe if your cyclosporine blood test is on the low side, instead of raising the dose of cyclosporine, could you take it with a small amount of grapefruit juice? Who knows?

Well, I did add grapefruit juice, a little bit cautiously, and my cyclosporine trough number is still low at 44, when doctor was looking for between 200 and 400. But, my CTP cycle seems to be affected, so that is enough for me, at this point. 

I've actually read that the trough number for cyclosporine, normally taken 12 hours after a dose will have a negligible increase after grapefruit juice. Its the peak that will go up by 185. So, I am asking for a peak test, 2 hours after dose.

Well, here's the rub. The doctor refuses to do a peak test, controlling... Medical and insurance doesn't like patients to have too much freedom... Can't win when you have your own ideas. I want to adjust doses and they want to adjust doses... They spend 2 minutes thinking, and I'm supposed to go by what they think?