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Danazol, low dose Promacta with a twist of slow remission

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7 years 1 month ago #64204 by momto3boys
Replied by momto3boys on topic Danazol, low dose Promacta with a twist of slow remission
Hooray for no negative effects from the gluten. I'm glad to hear your skin is doing better.
Regarding the count, honestly I wouldn't conclude any kind of a decline from going to 70 to 63 to 61. Considering the margin of error, those are all basically the same thing, so I would say that you are stable. Anything less than +/- 10 is basically the same count in my book.
So it looks like the promacta is doing really well for you and has you right in the target zone. Congrats!
The following user(s) said Thank You: Sandi, Hal9000
  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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7 years 1 month ago #64206 by Hal9000
Replied by Hal9000 on topic Danazol, low dose Promacta with a twist of slow remission
Note, between the 70 and the 63 there was a 67 and a 68. Forgetting that it is platelet count for a second, it really is a slowly declining 'number'. I am stunned by it's consistency too. Worse yet, when dosing at 50mg and then at 25mg all the counts were proportional to dose too! Finally when going to 12.5mg it got a little non linear. As I mentioned to Anne, the single data point for 12.5mg before Danazol is '52'.
Next time I see my doctor I'm going to tease her that 'I paid good money to their nurse to get those counts'.
ITP Types and Treatments by HAL
  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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7 years 1 week ago #64769 by Hal9000
Replied by Hal9000 on topic Danazol, low dose Promacta with a twist of slow remission

Hal9000 wrote: Latest count is 61...
...Expecting to restart Danazol @ 50mg in 6 weeks.

Latest count is 58. 12.5mg of Promacta.
Finally got both AST and ALT liver enzyme levels back into the 20s. ALT wasn't cooperating and was being stubborn in the 40s. So, the past 6 weeks I've been taking Vit B-complex and the last couple of weeks I added 'SAMe' to speed recovery.

Started Danazol @ 50mg. Continuing with Promacta. Expecting to cut back Promacta in a month or two, as on first try with Danazol. With any luck this drug will not be a problem long term at this low 50mg dose. My expectation going in here is that counts will rise to some value and level off. Then staying on for a year after that occurs. Give time for those T cells to roll over with fresh generations.
ITP Types and Treatments by HAL
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The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. The information contained herein is not intended nor implied to be a substitute for professional medical advice and is provided for educational purposes only. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment, discontinuing an existing treatment and to discuss any questions you may have regarding your unique medical condition.


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