Research on the role of H Pylori in ITP

The role of H Pylori in ITP has been controversial. This study seeks to clarify that role.
In all, 13 out of 60 patients responded to H Pylori testing and eradication.

pdfs.semanticscholar.org/882e/d2db5eebc22f8a5eb774aa908a41a31b64bd.pdf
Relevance between Helicobacter pylori Infection and Immune Thrombocytopenia
El-Kady, R.A., et al. (2017) International Journal of Hematology & Therapy 3(2): 1- 6.
Abstract
Objectives: This study was conducted to determine: the prevalence of Helicobacter
pylori (H. pylori) infection in adult patients with immune thrombocytopenia (ITP), [ii]
the response of H. pylori infected ITP patients to eradication therapy of H. pylori, [iii]
an anticipating factor for platelet response in H. pylori-infected ITP patients.
Methods: The study enrolled 60 adult patients diagnosed with ITP recruited to the
Outpatient Clinic of Haematology, Oncology Center of Mansoura University (OCMU),
Mansoura, Egypt. H. pylori infection was detected by faecal H. pylori antigen enzyme
linked immunosorbent assay (ELISA). Serum H. pylori anti-cytotoxin associated gene
A (anti-CagA) IgG titers were assessed by ELISA. ITP patients positive for H. pylori
infection received standard eradication regimen.
Results: H. pylori infection was detected in 33.3% of ITP patients. 13 patients (65%)
exhibited an increased platelet count after eradication therapy (treatment responders).
The decline in the titers of anti-CagA IgG after therapy was statistically significant in
responders (p = 0.005) compared to non-responders (p = 0.1).
Conclusion: H. pylori detection and eradication is recommended in adult patients with
ITP, so that farther harsh treatment approaches of ITP could be adverted in infected
patients. Moreover, anti-CagA IgG titer is a predictive indicator for platelet recovery
after eradication therapy