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Prednisone and prednisolone

  • karenr
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  • Diagnosed in 2000, at 59, after being on moderately high doses of NSAIDs for arthritis. Splenectomy and rituxan both failed (2004). Did well on prednisone till summer 2018--then terrible reactions. Promacta since 11-19.
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9 years 2 months ago #56897 by karenr
Prednisone and prednisolone was created by karenr
I've read that prednisolone is prednisone treated to bypass some steps and that it is more easily absorbed and may cause fewer problems than prednisone. Europeans seem to talk about prednisolone; Americans apparently are almost always prescribed prednisone. Can anyone explain this to me? Would prednisolone be a better option, and is it available in the U.S.?

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  • karenr
  • Topic Author
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  • Diagnosed in 2000, at 59, after being on moderately high doses of NSAIDs for arthritis. Splenectomy and rituxan both failed (2004). Did well on prednisone till summer 2018--then terrible reactions. Promacta since 11-19.
More
9 years 2 months ago #56901 by karenr
Replied by karenr on topic Prednisone and prednisolone
Sorry about this post appearing here. I was trying to post it under Treatments, and I don't know how it ended up here!

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9 years 2 months ago #56902 by Rob16
Replied by Rob16 on topic Prednisone and prednisolone
Prednisone is what is called a "prodrug", in that it only works after it has been converted by enzymes in the liver into prednisolone, the active form. A small number of people lack those enzymes, and for them prednisone doesn't work, while prednisolone does. I do not know what effects this might have on side effects.

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  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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9 years 2 months ago #56908 by mrsb04
Replied by mrsb04 on topic Prednisone and prednisolone
None from what i know Rob..the same horrid side affects as prednisolone

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Platelet Disorder Support Association

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IMPORTANT!

The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. The information contained herein is not intended nor implied to be a substitute for professional medical advice and is provided for educational purposes only. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment, discontinuing an existing treatment and to discuss any questions you may have regarding your unique medical condition.