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Question RE: Dex update

  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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9 years 2 months ago - 9 years 2 months ago #56516 by mrsb04
Replied by mrsb04 on topic Question RE: Dex update
Neither had I Rob 16, however !!!!!!!!!

References from emedicine.medscape.com/article/313842-overview?pa=d2h8M0SLVt9V1XD2JB1k7keyqM2lXhCVfDCukzu3%2FogLp3DfFgQRPvdLN6HrtIgI

Yamaguchi M, Niimi A, Minakuchi M, et al. Corticosteroid-induced myopathy mimicking therapy-resistant asthma. Ann Allergy Asthma Immunol. 2007 Oct. 99(4):371-4. [Medline].

Lacomis D, Smith TW, Chad DA. Acute myopathy and neuropathy in status asthmaticus: case report and literature review. Muscle Nerve. 1993 Jan. 16(1):84-90. [Medline].

Inder WJ, Jang C, Obeyesekere VR, et al. Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1 - implications for steroid-induced myopathy. Clin Endocrinol (Oxf). 2009 Aug 4. [Medline].

Betters JL, Long JH, Howe KS, et al. Nitric oxide reverses prednisolone-induced inactivation of muscle satellite cells. Muscle Nerve. 2008 Feb. 37(2):203-9. [Medline].

Kumar S. Steroid-induced myopathy following a single oral dose of prednisolone. Neurol India. 2003 Dec. 51(4):554-6. [Medline]. [Full Text].

Inder WJ, Jang C, Obeyesekere VR, Alford FP. Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1--implications for steroid-induced myopathy. Clin Endocrinol (Oxf). Jul 2010. 73(1):126-32. [Medline].

Levin OS, Polunina AG, Demyanova MA, Isaev FV. Steroid myopathy in patients with chronic respiratory diseases. J Neurol Sci. 2014 Mar 15. 338(1-2):96-101. [Medline].

Minetto MA, Qaisar R, Agoni V, et al. Quantitative and qualitative adaptations of muscle fibers to glucocorticoids. Muscle Nerve. 2015 Jan 16. [Medline].

Dekhuijzen PN, Decramer M. Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered. Eur Respir J. 1992 Sep. 5(8):997-1003. [Medline].

Borba A, Guil D, Naveso G, et al. [Oral steroids effects on the respiratory muscles function in severe asthmatic patients.]. Rev Port Pneumol. 2006 Dec. 12(6 Suppl 1):39-40. [Medline].

Stanton AE, Sellars C, Mackenzie K, et al. Perceived vocal morbidity in a problem asthma clinic. J Laryngol Otol. 2009 Jan. 123(1):96-102. [Medline].

Minetto MA, Botter A, Lanfranco F, Baldi M, Ghigo E, Arvat E. Muscle fiber conduction slowing and decreased levels of circulating muscle proteins after short-term dexamethasone administration in healthy subjects. J Clin Endocrinol Metab. Apr 2010. 95(4):1663-71. [Medline].

Danon MJ, Schliselfeld LH. Study of skeletal muscle glycogenolysis and glycolysis in chronic steroid myopathy, non-steroid histochemical type-2 fiber atrophy, and denervation. Clin Biochem. 2007 Jan. 40(1-2):46-51. [Medline].

Afifi AK, Bergman RA, Harvey JC. Steroid myopathy. Clinical, histologic and cytologic observations. Johns Hopkins Med J. 1968 Oct. 123(4):158-73. [Medline].

Dumitru D. Myopathies. Electrodiagnostic Medicine. San Antonio, Tex: University of Texas; 1995. 1031-129.

Ahlbeck K, Fredriksson K, Rooyackers O, et al. Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. Acta Anaesthesiol Scand. 2009 Jul. 53(6):717-23. [Medline].

Hanson P, Dive A, Brucher JM, et al. Acute corticosteroid myopathy in intensive care patients. Muscle Nerve. 1997 Nov. 20(11):1371-80. [Medline].

Uchikawa K, Takahashi H, Hase K, et al. Strenuous exercise-induced alterations of muscle fiber cross-sectional area and fiber-type distribution in steroid myopathy rats. Am J Phys Med Rehabil. 2008 Feb. 87(2):126-33. [Medline].

Batchelor TT, Taylor LP, Thaler HT, et al. Steroid myopathy in cancer patients. Neurology. 1997 May. 48(5):1234-8. [Medline].

Eddelien HS, Hoffmeyer HW, Lund EL, Lauritsen AO. Glucocorticoid-induced myopathy in the intensive care unit. BMJ Case Rep. 2015 May 24. 2015:[Medline].

Menezes LG, Sobreira C, Neder L, et al. Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats. J Appl Physiol. 2007 Feb. 102(2):698-703. [Medline]. [Full Text].

Pereira RM, Freire de Carvalho J. Glucocorticoid-induced myopathy. Joint Bone Spine. 2010 May 13. [Medline].

Yamamoto D, Maki T, Herningtyas EH, Ikeshita N, Shibahara H, Sugiyama Y. Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats. Muscle Nerve. 2010 Jun. 41(6):819-27. [Medline].

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The following user(s) said Thank You: Winnifred

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9 years 2 months ago #56522 by Winnifred
Replied by Winnifred on topic Question RE: Dex update
First off Thank you Rob16 and mrsb04

Wasn't sure your response was correct because I had forgotten to mention the pain I was having in the arm. So I read the link mrsb04 posted then did a quick google search for Corticosteriod induced myopathy. Apparently it can cause pain. More often just weakness but pain can happen too.

I'm sensitive to medications and side effects are usually magnified in me. (if it says may cause I know it will happen) When the doctor said my arm was a side effect of the dex I figured he said that because he could not find any other cause. I didn't realize it was actually a side effect.

This makes me smile for 2 reasons:
1. It's not my imagination
2. a quote from my sister "only you would have that happen"! hehehe

PS: mrsb04 give yourself a hug from me!
The following user(s) said Thank You: mrsb04

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9 years 2 months ago #56583 by Winnifred
Replied by Winnifred on topic Question RE: Dex update
Follow up from hospital cause my arm is still giving me trouble 1 week later. Family doctor says he highly doubts it was the steroid as it doesn't usually cause unilateral swelling. Swelling would be in both arms.

He feels there is soft tissue injury. He basically said I had injured my arm?? How I have no idea I'm stumped because I know I didn't bang it, twist it, or do a new activity with it.

He states normally he'd recommend NSAID's but because of ITP he can't. So he prescribed me PENSAID (sp) a topical liquid to apply. Said it should help heal without affecting my platelets.

So now I have no idea what to think or do. Do I just go with doctor #1 and blame the dexamethasone. Or go with doctor #2 and convince myself I injured my arm even though I don't remember doing anything?? UGH

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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9 years 2 months ago - 9 years 2 months ago #56584 by Sandi
Replied by Sandi on topic Question RE: Dex update
I am pretty sure that steroid myopathy only occurs after a lengthy time on steroids. I've been tested quite a few times since I have muscle weakness and have been on steroids for 10 years. It would more than likely affect both arms and both legs....it doesn't just pick one limb.

A topical? Wow, the things they do when they have no idea what to do.

I hope it clears up fast, Julia, whatever it is. That is a very strange thing to happen.

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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9 years 2 months ago #56585 by Sandi
Replied by Sandi on topic Question RE: Dex update
I woke up one morning about three years ago and couldn't use my left hand. The weakness was so bad that I could barely move my fingers. Couldn't even rip off a piece of toilet paper with that hand. No swelling, no pain. If I had gone to the Dr., they wouldn't have had a clue. I get so used to weird things like that I usually don't even go to the Dr. Bad habit.

Anyway, two days later, I noticed a burning sensation in my upper arm. Finally that night around midnight, I took a look at it in the mirror - it was close to my arm pit so I couldn't see it without the mirror. Anyway, I saw a small line of blisters and knew. Shingles! It hit the nerve and muscle before the rash even came out. Went to the ER and got the anti-virals, then spent four months doing PT. It never did come back fully, but I'm losing muscle in both hands now (for about a year) with no known cause (yet). Need to get the Neurologist still....too much going on to follow up.

Is it getting better?

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9 years 2 months ago #56587 by Rob16
Replied by Rob16 on topic Question RE: Dex update
Julia, I am quite hindered by shoulder surgery last monday, but i do want to comment, though without the usual citations. From my reading I have learned that there is an acute version of steroid myopathy, occurring at higher dosage, especially with a specific class of steroid which includes dexamethasone. Apparently this is not so uncommon when high dose steroids are used to treat asthma.

If you are planning more rounds of HD-Dex you may want to explore this possibility first.

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9 years 2 months ago #56590 by Winnifred
Replied by Winnifred on topic Question RE: Dex update
.
Sandi - After reading your post I went straight to the bathroom to look for signs of shingles. No signs this no way feels like when I had shingles on my back. Every day is a little better I can squeeze the toothpaste but still not where i'd like it to be. I am concerned with using the Pensaid as it is an NSAID's only topical so I'm only doing 10 drops BID instead of the 40 or 50 mentioned to me.

Rob16 - Here's hoping your shoulder heals in a timely manner. must be very painful!
After you and mrsb04 posted I started reading and have found the same info. Also found info referring to it affecting one extremity. When I see the hematologist on the 24th I'm going to ask her for an opinion and her experience with HDD causing steroid induced myopathy.

Words the last 2 doctor's used: "usually" "typically" making me wonder if I'm not just atypical. I'm beginning to think Ockham's razor is my answer.

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