How long can it take for IVIG to start working?

Hello,

I am newly diagnosed with ITP. I have been as high as 23 and as low as 15. I went to the ER on April 29 with a count of 18 and have been on prednisone between 60 mg and 40 mg ever since. I am currently being tapered (taper started a week ago) from 60 mg to 40 mg as it seemed to have no effect on my platelet count. I am currently taking 40 mg of prednisone for about a week. Because the prednisone was not working, I was ordered three days of IVIG which I did Monday, Tuesday, and today. Monday before I started my count was 22 and today just before starting the third round my count was 15. I was pleased Monday as my count remained stable even with the prednisone taper. I was disappointed that my count dropped after two days of IVIG, but my doctor reassured me that it could still work. Has anyone had a delayed response to IVIG? Also, to avoid the headaches associated with the IVIG I drank a lot (probably around gallons) yesterday as I felt a headache coming on. Has anyone noticed that their hydration level effects their platelet count?

Thank you for your help!

edit: probably around 2 gallons

IVIG should start to work in 24 to 72 hours. Some people do not get any response at all, but most do. IVIG is generally temporary and only lasts a few days to a few weeks.

Most people find that hydration can make a huge difference with headaches, as Aseptic Meningitis is a common side effect. Hydration, as far as I know, does not affect platelet levels.

Be careful drinking too much water too fast, especially when getting IV fluids. It can deplete your electrolytes and cause low potassium, magnesium, sodium, etc and can be dangerous. Tissues can swell and actually cause death. Read about safe amounts.

Is the 24 to 72 hours after the first infusion of the series or after the series is complete? Thank you!

Depending on the dose, usually after the first infusion. Most people do not get three of them. Sometimes, but not always.