Revolade 75 mg Doseage

I have been bumped up from 50 mg of Revolade to 75 mg per day. Anyone else out there on that high of a dose and if so any side affects?

Hi,

I started the same drug recently (under the Promacta name since I am in the US) and after almost 4 weeks with no platelet response my hematologist bumped my dosage up to 75mg. I stayed at that dose for about 2 weeks because I went on a trip and skipped one week of lab work. When I increased the dosage, I got only the mildest of "feverish" kind of feelings in the afternoon, which felt very vaguely like I was coming down with something. That only lasted maybe 2-3 days when I first bumped up the dose (I take my medication at 2:30 AM), then I went back to no side effects. When I first started taking the drug at 50mg, I had a few days of nausea, but that faded after about a week.

I got counts of 163,000 followed by 181,000 after that bump to 75mg. I've now titrated rapidly to 25mg (after 1 week at 50mg) and we'll see what the counts bring going forward.

Do you have any side effects on 50mg? Hopefully the 75mg will give you a nice kick like it did for me

(I'm asplenic, just for reference)

Hi,
Thanks so much for your reply. What great counts you have, I hope they stay up! Interesting that you only stayed on the 75 mg doseage for a short time. I'm not sure how long my doctor is planning on keeping me on it, I guess it depends on my count which I will get next week. I have been on 50mg for a year, with counts of 150,000 to 250,000. I suddenly crashed a couple of months ago, thus the increased doseag. The only side effects I had at the start of taking the drug a year ago was sore fingertips, particularily my right thumb. After suffering for a few months with this my doctor recommended taking a baby aspirin each morning which definitely did the trick. He figured because my body wasn't use to such high counts the platelets were clumping in my fingertip and causing alot of pain. It seems to be a good drug with minimal side effects. I take mine at 6:00 am and then don't eat for an hour after. Also avoid dairy and minerals for 4 hours after.
Good luck!

Hahaha, my counts prior to this drug were in the 20-40K range. I'm shocked that your doctor let you stay at such a high dosage while getting such high counts! They recommend that you use the drug to get close to the 50,000 level and not much above it. Especially with clotting fears I totally would have been bugging my doctor to go down if my counts were 150-200K for a year!

I hope that you can get more of a response with the 75mg, what have your counts fallen to that is prompting you to increase your amounts?

Be sure to read the dosing information that comes with the drug as well as what is available online. I find that knowing yourself how to use the drug can help you educate any doctors who may not be quite as current on the use of eltrombopag for ITP. Your counts were really way too high for this treatment for the last year, maybe it's just a matter of setting expectations of a "safe count" (50,000) versus a "normal count" (150,000+)

Maybe you have 50,000 and you won't need to up to 75mg after all Good luck!

I have been on 75mg for 3 months now and have had absolutely no side effects. I eat nothing after 7pm and take it at 11pm. However it does very little for my platelets except keep me above mouth and nose bleed level, around a count of 10. Once upon a time it was more effective but no longer. As I have marrow underproduction it does however seem to improve my red and white cell counts. I remain on it as it is a last resort for my platelets, since the rituxan I had in Dec has had no effect. Despite the low count I am well and active. I just can' t travel by air which is frustrating .