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Article re: pros and cons of treatments

  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #32487 by Sandi
Article re: pros and cons of treatments was created by Sandi
I came across this article today and have no idea how I missed it in my Bloodjournal updates. It's one of the most thorough treatment articles I've ever read, listing pros and cons of three common treatments.

bloodjournal.hematologylibrary.org/content/120/5/960.full?sid=9e00c230-10f8-405a-964d-299484e271a0
The following user(s) said Thank You: Nomad, Dori, Fervenz, johnmerrick
  • CindyAnn
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  • Diagnosed Jan 10, 2008. Rituxan treatment in May 2009. Treated with Prednisone off and on until 08/23/17 - 12.5mg Promacta as of 10/22/17
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12 years 5 months ago #32493 by CindyAnn
Replied by CindyAnn on topic Article re: pros and cons of treatments
This article sure makes a good argument for delaying a splenectomy. It also points out the many choices we as "ITPers" have to make.

Very good read!!!

Cindy Ann
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #32505 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
I think the article presents both sides well, but does give examples of when it is best to consider it and best not to.
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #32514 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
Here's another good article that I just found:

bloodjournal.hematologylibrary.org/content/118/16/4297.full?sid=6289f8c7-0a84-4a8d-93cb-7f281787cd36
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12 years 5 months ago #32523 by Vdeutsch85
Replied by Vdeutsch85 on topic Article re: pros and cons of treatments
Great article, one article says to wait 1-2 years before considering splenectomy and the other says 3
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #32528 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
I looked to see the time difference between the two articles...only 8 months. Different authors too. Oh well, safe to say they advise to wait one to three years!
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 5 months ago #32548 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
www.ncbi.nlm.nih.gov/pubmed/23637127
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12 years 5 months ago #32554 by Vdeutsch85
Replied by Vdeutsch85 on topic Article re: pros and cons of treatments
I think I will re-assess my situation in December....that will be the one year point for me. However, the more I read, the more against splenectomies I become.
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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12 years 4 months ago #33247 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
Here is a new article re: Rituxan and Dexamethasone. This has been published before, but the more this combination is studied, the more credible it becomes.

onlinelibrary.wiley.com/doi/10.1111/ejh.12102/abstract
The following user(s) said Thank You: Dori
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12 years 4 months ago #33255 by Vdeutsch85
Replied by Vdeutsch85 on topic Article re: pros and cons of treatments
Thank you for sharing!
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10 years 6 months ago #47722 by goaliegirl51
Replied by goaliegirl51 on topic Article re: pros and cons of treatments
I had a laproscopic splenectomy after having all possible treatments attempted. It worked great for about a month. Then my platelets plummeted again. I now have an n-plate injection every week.
  • EmilyK
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  • Diagnosed jan 2015 at age 50 with 13,000 platelets.
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10 years 6 months ago #47723 by EmilyK
Replied by EmilyK on topic Article re: pros and cons of treatments
How is the NPlate working for you?
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10 years 6 months ago #47725 by goaliegirl51
Replied by goaliegirl51 on topic Article re: pros and cons of treatments
Well it does the job. Generally you're supposed to keep the platelets between 50,000 and 150,000, but I'm so messed up I don't actually follow all of the FDA recommendations. In general though, I'd say it's painless. You have to stay on top of it. If you miss a dose, your count will plummet. My doctor advised me to use Nplate instead of the promacta pill because apparently the pill is a bigger pain and diet restrictions. Supposedly most people dislike the pill way more than Nplate.
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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10 years 6 months ago #48147 by Sandi
Replied by Sandi on topic Article re: pros and cons of treatments
Goalie:

It's in your best interest to follow the Guidelines for N-Plate. Not doing so can be dangerous. Counts should actually be maintained around 50k and your doctor should be dosing you in that manner.
  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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10 years 6 months ago #48150 by mrsb04
Replied by mrsb04 on topic Article re: pros and cons of treatments
Interesting reads thank you Sandi
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