Low Dose Naltrexone for ITP

Has anyone had any experience with using low dose Naltresone for treating ITP? My alternative internal medicine MD strongly recomnended giving it a try as it has been very effective in turning around many autoimmune conditions. Please let me know if anyone has tried it yet.

No, no one has tried it that I know of. It's been discussed once or twice. I tried to get it prescribed for Lupus, but my Rheumatologist wouldn't do it.

Has anyone tried this yet? It seems to help people with other autoimmune disorders. I was prescribed it for Lyme disease. I think I took too high a dose to start with and it just made me horribly nauseous all day every day I took it and it can and did cause at least one night of absolutely bizarre dreams. I'll definitely try it again in a lower dose if it could help with my platelet count. A lot of these Lyme drugs and supplements can be blood thinning so it would be helpful.

nn.neurology.org/content/1/3/e25.full

This article is saying that it can possibly worsen ITP. LDN has been around for at least a little while now and there doesn't seem to be much info on it relating to ITP. I imagine that probably means it's not an effective treatment.

I haven't heard that drug mentioned for a very long time. As far as I know, no one here has used it for ITP. It's just not a standard treatment.

I've come across LDN therapy many times recently when reading about management of chronic pain. But nothing I've read suggested any benefit for thrombocytopenia in any form, though ITP was never mentioned specifically.

A quick search in PubMed resulted in two articles under the keywords "ITP and naltrexone" but no results under "thrombocytopenia and naltrexone". The former result was due to one person developing ITP during a naltrexone trial, and the latter because ITP doesn't only refer to immune thrombocytopenic purpura. Even a search under the keywords "platelet and naltrexone" only yields nine results, and none of these articles are related to platelet disorders.

Yeah, my pain isn't so bad these days. It supposedly can boost your immune system, which for autoimmune isn't great but would be helpful for Lyme. And it's supposed to help people with autoimmune issues. So I thought it might be what I need to balance the ITP and lyme issues but nothing I've seen shows any benefit for ITP either. It's supposed to increase your bodies natural endorphin levels. Things meant to alter neurotransmitters never seem to work for me. I think I'll definitely hold off on this one for now.