Has anyone access to BJH-Articles?

Hi everyone. Does anyone have access or does know a way to get the following article:

"Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents." Br J Haematology, 2011 Sep 9, Ghanima W et al

Thanks

You could contact your local public library and they could help you get the article.
Erica

Here is an abstract:

Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents. [JOURNAL ARTICLE]
Br J Haematol 2011 Sep 9.


This study assessed the grade of bone marrow (BM) fibrosis and its association with a seromarker for collagen-III formation and fibrosis-related cytokines in 25 immune thrombocytopenia (ITP) patients treated with thrombopoietin receptor agonists (Tpo-RA) who had at least one BM biopsy. Assessment of 8 pre- and on-treatment BM biopsies revealed statistically significant increases in reticulin. Reticulin in biopsies performed after a median of 1·4 years of treatment was graded: MF-0 in 3 (12%), MF-1 in 19 (76%), MF-2 in 2 (8%) and MF-3 in 1 (4%). No cytogenetic or flow-cytometric abnormalities were detected. Median pretreatment Procollagen III N-propeptide (PIIINP) (6·6 μg/l) was significantly higher than on-treatment levels (5·6 μg/l); both were higher than controls (3·4 μg/l; P < 0·001). PIIINP was negatively correlated with treatment duration (r = -0·49) suggesting a decelerated reticulin production over time. There was a trend towards an association between grade of reticulin and PIIINP. Transforming growth factor (GF)-beta and basic-Fibroblast GF were not different between patients and controls but Hepatocyte GF (HGF), an anti-fibrotic cytokine, was significantly elevated in patients. In conclusion, low-grade BM reticulin fibrosis is seen in most ITP patients on Tpo-RA. The novel findings of decreasing PIIINP and elevated HGF need further investigation to explore their significance in BM fibrogenesis.


www.unboundmedicine.com/medline/ebm/record/21902682/abstract/Fibroproliferative_activity_in_patients_with_immune_thrombocytopenia__ITP__treated_with_thrombopoietic_agents_

Thanks Sandi,

i already read the abstract. Would have liked to read the full. Haven't got access to BJH. Only NEJM, Blood etc.

MY nhs athens login doesn't seem to work for that which is pretty pathetic really. But there you go.