Asking people with fluctuating platelets numbers, do you notice that the monocytes go high when the platelets go high? Mine do. I believe it is showing the immune response, to fight the platelets. I guess the body thinks that high platelets is a disease to fight (or any platelets is a disease to fight, unfortunately).
I wonder if this (monocytes going up with platelets going up) may not happen when your problem is production. But then, maybe you don't have the wild fluctuations in platelets, so wouldn't be as noticeable for you, anyway.
Can this be a way of determining the actual individual (your own personal) reasons for low platelets, personally wondering... Of course, it would be nice if when the platelets go low, that the lower count of monocytes would leave them alone, but that does not seem to be happening, either. The platelets still do bottom out.