YES withdrawal from prednisone can cause joint and muscle pain, weakness, tiredness. When I got off steroids, I had trouble walking when I got off work, just so tired and all my joints ached. It took a long time to recover, maybe 6 mos. It depends on how long you were taking prednisone and how high the dose was. Also if you are under stress or not getting enough sleep, you will feel the effects of withdrawal more. You need a lot of sleep to heal the adrenals after being on prednisone. Sleep is really the answer. Also I got off sugar and that helped me feel less achy, I get inflammation from sugar and white flour, potatoes, pasta.