Platelet Disorder Support Association

Join Us:

Become a Member

Support Us:

Make a Donation
    Remember Me     Forgot Login?   Sign up   •  Web site Help & Info
!!! DISCUSSION GROUP RULES !!!

1. You must be a registered website user in order to post and comment. Guests may read only.
2. Be kind and helpful, not rude and cynical.
3. Don't advertise or promote anything. You will be banned from the group.
4. Report problems to the moderators. THANK YOU!

Platelet antibody

More
6 years 4 months ago #66701 by Angelito0130
Platelet antibody was created by Angelito0130
Hello, 16 month old daughter was diagnosed with ITP on March 4th, a few days ago her hematology did PLATELET ANTIBODY, DIRECT (IGG)
Plt Associated Anti-IIB/III positive Plt Associated Anti-IB/IX positive
Plt Associated Anti-IA/IIANegative
Do you guys have any clue about the meaning of the reults?
Thank you
More
6 years 4 months ago #66717 by lurpelis
Replied by lurpelis on topic Platelet antibody
These are tests for antibodies against molecules which are known to be potentially on platelets. The positive antibodies test could indicate autoimmune activity against platelets. As of now I do not believe positive or negative platelet antibody tests alter course of treatment, but help to confirm ITP.
The following user(s) said Thank You: Angelito0130
More
6 years 4 months ago #66718 by Angelito0130
Replied by Angelito0130 on topic Platelet antibody
Before the results, her hemo wants to do a bone marrow biopsy, but after the results I hope doctor change his mind about doing a biopsy!!!
  • Hal9000
  • Offline
  • Give me all your platelets and nobody gets hurt
More
6 years 4 months ago - 6 years 4 months ago #66719 by Hal9000
Replied by Hal9000 on topic Platelet antibody
Angelito, the immune system is very complex. Those 3 tests identify which antibody groups are potentially attacking platelets. There is a lot of good general information on Wikipedia:
... "Most often these antibodies are against platelet membrane glycoproteins IIb-IIIa or Ib-IX, and are of the immunoglobulin G (IgG) type." ...
en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura

I suspect that your doctor was trying to eliminate familial/congenital Thrombocytopenia as a possible diagnosis. One would expect all three to be negative in that situation. See the end of this study's abstract:
"Prospective evaluation of a new platelet glycoprotein (GP)-specific assay (PakAuto) in the diagnosis of autoimmune thrombocytopenia (AITP)"
www.ncbi.nlm.nih.gov/pubmed/15726595
ITP Types and Treatments by HAL
The following user(s) said Thank You: Angelito0130
More
6 years 4 months ago #66730 by lurpelis
Replied by lurpelis on topic Platelet antibody
Bone marrow biopsy is a very common approach to ITP diagnosis, it's to ensure there is no other cause like cancer or a different rare blood condition. I had one done and it is minimally invasive and I recovered quickly and with little to no pain.

Though it sounds scary, it's arguably one of the best tools to make sure they diagnose your daughter correctly.
The following user(s) said Thank You: Angelito0130
Platelet Disorder Support Association

Donate

About

Stay Informed

Follow Us

IMPORTANT!

The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. The information contained herein is not intended nor implied to be a substitute for professional medical advice and is provided for educational purposes only. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment, discontinuing an existing treatment and to discuss any questions you may have regarding your unique medical condition.


Platelet Disorder Support Association
8751 Brecksville Road, Suite 150, Cleveland, Ohio 44141
Phone: 1-87-PLATELET | 877-528-3538 (toll free) | or 440-746-9003
E-mail: pdsa@pdsa.org


© Copyright 1997 - 2025, Platelet Disorder Support Association. All rights reserved.
The Platelet Disorder Support Association is a 501(c)3 organization and donations are tax deductible to the fullest extent allowed by law.


Privacy Policy and Terms of Use