Platelet Disorder Support Association

Join Us:

Become a Member

Support Us:

Make a Donation
    Remember Me     Forgot Login?   Sign up   •  Web site Help & Info
!!! DISCUSSION GROUP RULES !!!

1. You must be a registered website user in order to post and comment. Guests may read only.
2. Be kind and helpful, not rude and cynical.
3. Don't advertise or promote anything. You will be banned from the group.
4. Report problems to the moderators. THANK YOU!

News Article: Platelet formation mechanism

More
10 years 4 months ago #48723 by delta809
News Article: Platelet formation mechanism was created by delta809
This article was from January this year so assuming this may not be new to everyone. I searched and did not find it posted so I thought I would post.

Scientists discover a new blood platelet formation mechanism

Summary:
A new cellular mechanism, called the endocycle, encourages the formation of platelets, the cells needed to coagulate blood. In mouse models, endocycles can help to control thrombocytopenia, a disease caused by a deficit in platelet production that causes heavy haemorrhaging. The new process could act as an alternative source of platelets when the normal mechanisms fail.

www.sciencedaily.com/releases/2015/01/150126124727.htm

www.ncbi.nlm.nih.gov/pubmed/25625205
  • Sandi
  • Offline
  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
More
10 years 4 months ago #48725 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
Hmmm. I wonder if it also applies to ITP?
  • mrsb04
  • Offline
  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
More
10 years 4 months ago #48735 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Me too Sandy as deficient platelet production is only one possible cause of ITP. My ITP for example is caused by excessive platelet destruction
  • Sandi
  • Offline
  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
More
10 years 4 months ago #48737 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
Curious, how do you know that?
  • mrsb04
  • Offline
  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
More
10 years 4 months ago - 10 years 4 months ago #48752 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Indium scan showed splenic destruction of platelets & bone marrow biopsy proved platelet production fine..in fact on overtime producing extra platelets attempting to make up for deficit. Hence my opting to enrol on the fostamatininb trial.
  • Sandi
  • Offline
  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
More
10 years 4 months ago - 10 years 4 months ago #48754 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
pdsa.org/forum-sp-534/6-general-itp-discussion/11698-bone-marrow-biopsy-and-production-answers.html

I thought there was some new way to discover production vs destruction.
  • mrsb04
  • Offline
  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
More
10 years 4 months ago #48756 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
I read my own biopsy results & watched my indium scan therefore know how rapidly my platelets are being destroyed. I believe them
  • EmilyK
  • Offline
  • Diagnosed jan 2015 at age 50 with 13,000 platelets.
More
10 years 4 months ago #48757 by EmilyK
Replied by EmilyK on topic News Article: Platelet formation mechanism
Mrs B
How are things going on the trial? I think you ow get the real drug, correct?
  • Sandi
  • Offline
  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
More
10 years 4 months ago #48763 by Sandi
Replied by Sandi on topic News Article: Platelet formation mechanism
I believe the Indium as far as destruction, I'm not questioning that. It's just that the bone marrow biopsy results do not prove that production is adequate even though that is a common belief. We've all shown adequate production results based on the number of megakaryocytes, but it is a misconception discovered in the past few years. Few doctors know this. Dr. Provan does, he's a good one to ask.
  • mrsb04
  • Offline
  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
More
10 years 4 months ago - 10 years 4 months ago #48766 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Cheers for that Sandi I will discuss with my consultant
  • mrsb04
  • Offline
  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
More
10 years 4 months ago #48767 by mrsb04
Replied by mrsb04 on topic News Article: Platelet formation mechanism
Too soon to Say Emily I've only been on it 6 days. Have a repeat count on June 1st
The following user(s) said Thank You: EmilyK
Platelet Disorder Support Association

Donate

About

Stay Informed

Follow Us

IMPORTANT!

The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. The information contained herein is not intended nor implied to be a substitute for professional medical advice and is provided for educational purposes only. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment, discontinuing an existing treatment and to discuss any questions you may have regarding your unique medical condition.


Platelet Disorder Support Association
8751 Brecksville Road, Suite 150, Cleveland, Ohio 44141
Phone: 1-87-PLATELET | 877-528-3538 (toll free) | or 440-746-9003
E-mail: pdsa@pdsa.org


© Copyright 1997 - 2025, Platelet Disorder Support Association. All rights reserved.
The Platelet Disorder Support Association is a 501(c)3 organization and donations are tax deductible to the fullest extent allowed by law.


Privacy Policy and Terms of Use