I found I had to keep having the dose moved up to keep getting good counts, then it seemed I no longer responded to the drug. I had a year of good counts before i had no response. I had a disastrous 2 weeks trying to get off it as it seemed to be a waste getting it with no response at the extraordinary cost.I was at a dose of 300 at that time and my count was consistently under 10. The only way to stop my bleeding when I stopped the NPlate was to give me a double dose (600) for a few weeks. That was in October. The dose has since been slowly lowered to 350 and I now have counts that range from 667 to 97. Side effects started at the extreme doses and seemed to coincide with the high counts.
My doctor told me they find that sometimes just the right dose makes all the difference with this med. For me, 300 was not enough and 350 seems like too much! Hope this helps.
