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Clotting Disorder

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14 years 6 months ago - 14 years 6 months ago #14300 by heidio
Clotting Disorder was created by heidio
Hi all. I recently posted how I just had a miscarriage on April 1st. I met with my OB today and she is trying to rule out a clotting disorder. I have tested negative the past two tests for Anti-Phos-Anti Syn (APAS). She thinks there may be a clotting disorder causing my miscarriages. I have had ITP for about 4 years. I have had one positive test for APAS in the past 3 years. My question is: are there any meds I can take instead of baby aspirin to help me if I do have a clotting disorder-one that won't bring my plat. count down? Anyone dealt with this? How badly does baby aspirin mess up our platelets?
Thanks so much!
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 5 months ago #14323 by Sandi
Replied by Sandi on topic Re: Clotting Disorder
Heidi:

I'm sorry to hear about your miscarriages. That must be tough.

I have had APS antibodies also. I tested positive a few times for Anticardiolipin Antibodies and also tested negative a few times. The Antibodies can come and go. The safest route if you have not had a clot is aspirin. I've been on aspirin for a few years and it has not affected my platelet count at all. Aspirin usually doesn't...it thins the blood but does not affect the count. I am only supposed to stop taking it if my counts go under 50, which they haven't.

I've read a few articles that actually stated that the body may compensate for APS by lowering the platelets on purpose, thereby avoiding a clot. Since the clotting can be more serious than ITP, I would actually rather have counts between 50 and 150.

Do you know which antibody you tested positive for? There are three.
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14 years 5 months ago #14334 by heidio
Replied by heidio on topic Re: Clotting Disorder
Sandi-
Thank you for your compassion.

It is encouraging to know that aspirin is ok. Is there a smaller amount than "baby" aspirin? Are you on "baby" aspirin?

In Feb 2009, my coagulation was:
ANTI-B2GP1 IGM 35.7
Anti -B2GP1 IGA 20.3
Phosphatid IGG 16.4
Phosphatid IGM 6.1

Cardiolipin IGG 17.9
Cardiolipin IGA 4.0
Cardiolipin IGM 9.5

Does that help? Which three should I focus on?
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 5 months ago #14355 by Sandi
Replied by Sandi on topic Re: Clotting Disorder
Heidi:

Without the reference ranges, I don't know what those results mean. I can decipher a lot of blood work results, but this isn't one of them. There are three antibodies:

1. Anticardiolipin antibodies (IgG, IgM, and IgA)

2.Lupus anticoagulant – a panel of blood clotting tests that may include the dilute Russel Viper venom time (dRVVT), lupus aPTT, mixing studies, and hex phase phospholipid test, platelet neutralization procedure

3.Antibodies to b2-glycoprotein I (IgG, IgM, IgA)

The worst one to have is the Lupus Anticoagulant.

Here is a good web site to read about it:

www.apsfa.org/aps.htm

There isn't anything that I'm aware of that is lower dose than baby aspirin, but that is what is recommended. Yes, I do take it. 89 mg's a day.
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14 years 5 months ago #14363 by heidio
Replied by heidio on topic Re: Clotting Disorder
Thanks Sandi! You are always so helpful with all of us!!
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