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Can ITP Cause Plaque Build-Up

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1 month 2 days ago #74017 by Robert1959
Can ITP Cause Plaque Build-Up was created by Robert1959
I haven't posted for many years now as my ITP experience ended some 12 years ago.
A brief history before I get to my query.
I was a 54 year old male when I first developed ITP in January 2014 and ended up being a severe refractory patient.
I was given Prednisone, IVIG, Cyclosporine, Dapsone, Rituximab, Dexmethasone and Romiplostim (NPlate) before miraculously my platelet count returned to normal in December 2014. During this time my lowest count was 0 and on NPlate I did the roller coaster above the normal range and peaked at 1.2 million for a couple of weeks.
During this time and occasionally since when getting blood tests, I have had to get them redone in citrate as my platelets were clumped.
My query is, does anyone have any knowledge or experience if ITP can cause any plaque build-up in your arteries.
My GP suggested recently during my yearly health checks that I get a calcium score test done as my cholesterol levels have always been just above the standard range (ie 5.5 total with the 'good' reading normal and the 'bad' just above the normal range) but nothing of any real concern.
Anyway my calcium score was 1000 which is in the 90% bracket.
This was a total surprise and so I was sent to a cardiologist for further tests.
I did really well on the stress test treadmill and further blood tests were in the normal range however I had numerous plaque blockages, in particular around my heart.
I cannot understand the reason for this as I am a non-smoker, physically very active, had a good diet, have not had any chest pain or breathlessness and have no family history of heart disease.
I then had a coronary angiogram done with the hope of just having some stents however the situation was worse than expected and I am now scheduled to triple bypass at the end of March.
I had wondered if the treatments I was given could result on plaque build-up but Dr. Google said no (putting aside the very high platelet count when on NPlate).
I then thought I would check to see if ITP itself could result in plaque build-up and the response was that it could especially as the new platelets could be sticky and so I am wondering if ITP could be the culprit.
I apologise for this being a bit long-winded.
Regards Robert

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4 weeks 2 days ago - 4 weeks 2 days ago #74018 by Itpjourney
Replied by Itpjourney on topic Can ITP Cause Plaque Build-Up
I am very sorry you're going through this. This is big news, though!

This article says Platelet-to-Lymphocyte Ratio should be more like 106 than 141. Of course it could be much higher than 141. Mine goes higher cyclically, for sure. Since I have relatively low absolute lymphocytes. Good to know. Thank you for the heads up. I guess there's more to worry about... 

Maybe that's why Nplate says not to go over 200, I suppose depending on lymphocyte values. Who knew? Can we raise lymphocytes while we're at it?

pmc.ncbi.nlm.nih.gov/articles/PMC5336865/
The following user(s) said Thank You: Robert1959

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