I've done a quick scout around for NHS (UK) guidelines; these are recommended as first line investigations for CVID
-Complete blood cell count with differential
-Total IgG, IgA, IgM and IgE levels
-Serum (and urine) electrophoresis
-Complement levels
-Functional antibodies (Tetanus, Hib and Pneumococci)
-IgG antibodies to previous infections and/or immunisations e.g. hepatitis B, meningococcus C, measles, rubella, CMV, VZV, EBV and others if appropriate
-If specific antibody levels are low, test immunisations (e.g. tetanus toxoid, pneumovax, Hib) should be given. Post immunisation blood samples should be taken after 4-6 weeks
-Lymphocytes subsets including T, B and NK cell numbers
-Switched memory B-cells (CD19+IgD–CD27+) and nonswitched (CD19+IgD+CD27+) memory B cells in the peripheral blood to identify patients with increased risk of bronchiectasis, splenomegaly or autoimmune disease
-Liver function tests, urea & creatinine, calcium
-Urine analysis