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N PLATE

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8 years 1 month ago #60300 by DUHEIL
N PLATE was created by DUHEIL
How long does n plate take before it starts to raise platelet levels?? My platelets are in the 20's. So far we have tried IVIG, steroids, and promacta with little success. Any other ideas??
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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8 years 1 month ago - 8 years 1 month ago #60301 by Sandi
Replied by Sandi on topic N PLATE
It can work right away or it can take a few weeks, depending on the dose. I'd stick with N-Plate for a while and see what happens. If that doesn't work, try Promacta again.
  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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8 years 1 month ago #60303 by Hal9000
Replied by Hal9000 on topic N PLATE
When you say little success do you mean no reaction to IVIG, or, it brought up counts for a week? How long did doctor give Promacta and did it bring counts up at all?
ITP Types and Treatments by HAL
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8 years 1 month ago - 8 years 1 month ago #60305 by poseymint
Replied by poseymint on topic N PLATE
Hi Duheil - When using Nplate the doses will kind of build upon one another. This is my experience and what I've seen in others. The first week the dose often won't bring it up much- say from 7K to 15K. Then the second dose will bring it up more as it piggy-backs onto the first dose. And by the third dose the counts will usually get up to where that dose will take you. Its a tricky drug. What I learned from my hematologist- you pick a dose that will get you to 50K. Give it time to work. Then leave it alone. That will make sense as you get more experience with Nplate. Its my favorite drug for ITP- hope it works for you!
The following user(s) said Thank You: DUHEIL
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8 years 1 month ago #60306 by DUHEIL
Replied by DUHEIL on topic N PLATE
No reaction to IVIG and promacta only raised it up from 20 to 27.
  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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8 years 1 month ago - 8 years 1 month ago #60308 by Hal9000
Replied by Hal9000 on topic N PLATE
I'd stick with it till the cows come home if necessary. For some folks it's almost like it has immune system regulatory powers over time.
ITP Types and Treatments by HAL
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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8 years 1 month ago #60309 by Sandi
Replied by Sandi on topic N PLATE
How long were you on Promacta and what dose?
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8 years 1 month ago #60313 by DUHEIL
Replied by DUHEIL on topic N PLATE
30 days at 50 mm
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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8 years 1 month ago #60314 by Sandi
Replied by Sandi on topic N PLATE
It would have been possible to raise the dose to 75. Some people have had success with that and were able to lower the dose in time. Sometimes you have to stick with the TPO's for a while to see a response.
  • thomaskm
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  • Male 69 Diag. April 2017 in ER with Petechiae from knees to toes 4 oral cheek blood blisters 3000 count. 3-IVIG rescues, 4, 4 day 40mg Dexamethadrone blasts. Best read 416,000 11/24/2020 (Covid+ bump) On Nplate maintenance every 3 weeks
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8 years 1 month ago - 8 years 1 month ago #60320 by thomaskm
Replied by thomaskm on topic N PLATE
DUHEIL, my reaction to Nplate was immediate thankfully. My first dose 1MCL / kg took me from 74 to 120, but I also responded to IVIG and steroids very well also, hitting a high of 217 and going without treatment for 5 weeks until starting Nplate. It is a weekly injection that consumes my Monday mornings but I tolerate the dose fairly well. Yesterday I was at 143 and asked to have my dose reduced but that was denied. Best of luck! There is an interesting video on the Nplate web site you might want to watch. On a side note: I get my injection at a local cancer treatment center staffed by 5 hematologists. Yesterday I asked the Dr. how many other patients are getting Nplate here. He paused a moment, looked at the ceiling then said, just you!
  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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8 years 1 month ago #60321 by Sandi
Replied by Sandi on topic N PLATE
That would explain his reluctance to lower the dose when your counts are above the recommended level. Hopefully, he keeps an eye on that!
  • mrsb04
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  • ITP since 2014. Retired nurse. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use.
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8 years 1 month ago #60326 by mrsb04
Replied by mrsb04 on topic N PLATE
thomaskm
I hope that was a typo '1ml/kg' and you meant 1mcg/kg
  • thomaskm
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  • Male 69 Diag. April 2017 in ER with Petechiae from knees to toes 4 oral cheek blood blisters 3000 count. 3-IVIG rescues, 4, 4 day 40mg Dexamethadrone blasts. Best read 416,000 11/24/2020 (Covid+ bump) On Nplate maintenance every 3 weeks
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8 years 1 month ago #60332 by thomaskm
Replied by thomaskm on topic N PLATE
Thanks! It was not a typo, it was an "old brain error". I will blame it on the ITP.
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8 years 1 month ago #60552 by jayinchicago
Replied by jayinchicago on topic N PLATE
My opinion is NPlate is so expensive is it makes no sense to waste it.

I get once in 3-4 weeks 2.9 mcg\kg wait for count to be below 50.
  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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8 years 1 month ago #60608 by Hal9000
Replied by Hal9000 on topic N PLATE
DUHEIL, are you up to a '3' dose level of Nplate yet? That is, 3 micro-grams per kilo-gram of body weight.
ITP Types and Treatments by HAL
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