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Platelets can reproduce in circulation?

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14 years 5 months ago #346 by Carola
Kind of interesting...The attached article says that platelets can reproduce in circulation.

www.sciencedaily.com/releases/2010/01/100126133352.htm

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 5 months ago #348 by Sandi
Replied by Sandi on topic Re:Platelets can reproduce in circulation?
Wow - that's some big news!

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14 years 5 months ago #389 by tortie
Replied by tortie on topic Re: Platelets can reproduce in circulation?
I'm saving this one on my favorites!!!! I'm trying to hang on for new treatments and this one sounds promising to me.

Michelle

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  • youngjoan
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  • I founded PDSA after recovering from ITP (7 failed treatments,zero count.) Read my story on the web site (search on 'success story.)Read more about me and my book, Wish by Spirit, at www.joanyoungwrites.com
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14 years 5 months ago #396 by youngjoan
Replied by youngjoan on topic Re:Platelets can reproduce in circulation?
I attended a session at ASH where this was presented and wrote a small article about it for the next issue of the platelet news. The platelet multiplication was a surprise to everyone. The researchers are continuing to determine how this happens, what stops it (some drugs), what doesn't interfere (ex. TPO), and how platelets seem to 'know' there are not many of them so they multiply more.

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  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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14 years 5 months ago #402 by Sandi
Replied by Sandi on topic Re:Platelets can reproduce in circulation?
I would have thought multiplication was due to fragmenting, but apparently not.

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14 years 5 months ago #417 by lili
This is very interesting. It might explain why some treatments work on some people and not others. I'm looking forward to your article Joan.

Lily

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  • youngjoan
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  • I founded PDSA after recovering from ITP (7 failed treatments,zero count.) Read my story on the web site (search on 'success story.)Read more about me and my book, Wish by Spirit, at www.joanyoungwrites.com
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14 years 5 months ago #418 by youngjoan
Replied by youngjoan on topic Re:Platelets can reproduce in circulation?
In the pictures, the platelets stretch into the typical dumbbell shape that is usually seen in cell division, then split. Dr. Weyrich is sending a picture for PDSA to publish in the next issue of The Platelet News.

This finding must make it really difficult for the manufacturers of the platelet counting machines since it is one more shape to consider. It might also help explain why the counters can be inaccurate at low numbers.

Dr. Weyrich found that when he had fewer platelets in his cultures the platelets divided more rapidly then when there were more platelets.

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14 years 5 months ago #430 by Carola
Replied by Carola on topic Re:Platelets can reproduce in circulation?
fascinating. I hope the researchers can use this information to invent new treatments!

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  • Kim
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  • Diagnosed with ITP in 1983, lupus in 1990, APS in 2001, vasculitis in 2006. Current platelet count 148. In 2007 I had a stem cell transplant for autoimmune disease and currently ITP and APS remission, with a reduction in lupus activity.
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14 years 5 months ago #434 by Kim
One thought I have on how the body knows circulating platelets need to split, divide, fragment (whatever you want to call it) is by the size of circulating platelets. ITP patients have large platelets, because of increased production, due to destruction, so does the body identify that and send out some type of signal to tell them to split? Does the body identify that the production of platelets is revved up to compensate for reduced platelet circulation and when the production is at peak performance, the bone marrow produces a different type of platelet, one that has a preprogrammed way to divided, event thought technically it should be able to, since it does not have a nucleus. Patients who are loosing platelets due to bleeding, also have larger younger platelets. When does a persons platelets make this division? Is it only when population of platelets is low, or is this a normal circumstance for everyone? Just another way to keep platelet population at adequate numbers, or a way to compensate for reduced numbers?

I can't wait to hear more about this research...exciting news.

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14 years 5 months ago #645 by Jenuk
Replied by Jenuk on topic Re:Platelets can reproduce in circulation?
Great article, thank you.

I like your theory Kim, sounds very feasible. It is strange to have cell division without a nucleus. I only remember the basic teachings at school in relation to the amoeba.

If anyone comes across any more info on this I'd love to be informed please.

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