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TOPIC: Wife - Low Platelets

Wife - Low Platelets 5 days 16 hours ago #66764

  • thomasjohnwood
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Hi everyone,

Back for the weekly update:

Week 0 - Diagnosis: 18K
Week 1 - Pre-Treatment: 19K
Week 2 - Treatment (4 doses of Dexamethasone): 165K
Week 3 - No Treatment (Menses): 13K
Week 4 - No Treatment: 30K
Week 5 - No Treatment: 64K
Week 6 - Treatment (4 doses of Dexamethasone & Menses): 127K
Week 7 - No Treatment: 33K
Week 8 - No Treatment: 53K

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Wife - Low Platelets 3 days 12 hours ago #66770

  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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Second pulse is looking more like the first one, post menses.
With the gradual increase afterwards, it is almost like, would counts rise to normal levels with no menses?

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Wife - Low Platelets 3 days 6 hours ago #66777

  • Lman
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  • We cannot change the cards we are dealt, just how we play the hand.
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Hal
I forgot to mention my response to dex when I was admitted to hospital .
I was given dex 4 times ( as a rescue ) each time it was for two days which I was in hospital .
I think dex pulse is four a four day treatment and I'm not really sure if the dose I was given was high enough (However , I can check from the report).
in both times and by all tests that I gave (including the day and the day later when I was discharged ) and even a week later .
They never rose above 22k ! How people have such a nice response to dex ?
And second thing , I was once given 11 units of platelets with initial count of 1 and a minor bleeding . couple of hours later counts were 2k !!
I read somewhere that each unit gives a healthy person +50k ... That's ironic :)

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Wife - Low Platelets 2 days 9 hours ago #66787

  • Hal9000
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lman, the strong Dex response is because of different antibodies, wouldn't you think? Because of different ITP pathophysiologies, and with that, different inflammation pathways. Steroids works for one pathway. Cyclosporine works for another. Recall this one on inflammation and transplants.
"An Update on Immunosuppressive Medications in Transplantation"
www.fmshk.org/database/articles/897.pdf

On platelets. The hospital pumped me full of platelets for my appendicitis surgery. Three bags of platelets before surgery and an additional bag during surgery, to be exact. The first 3 bags got my counts up to 50s. They wanted >50.

I think, because I have a TPO antibody / production problem, and not a platelet destruction problem, it was easier for them to overcome low counts with platelet transfusions then they may have found with you. And so. Because one's immune system can only destroy so much at a time, the first platelet transfusion is consumed quickly. Once the phagocytes are consumed, then counts can rise.
The following user(s) said Thank You: Lman

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