Eltrombopag Combined with Low-Dose Rituximab in the Treatment of Adult Immune Thrombocytopenia with Autoantibodies

This study takes place within the Institute of Hematology & Blood Diseases Hospital and is a prospective, open-label, nonrandomized, multi-center trial designed to compare the efficacy and safety of using eltrombopag with low-dose rituximab vs the best available therapy (therapy not consisting of eltrombopag coupled with rituximab) for adults between 18-65 years of age who have autoantibody failure due to intolerance or resistance to first-line therapy options. Participants with secondary ITP will be included.  Participants will be excluded from participating if they have active secondary thyroid disease or have a psychiatric disorder clinically diagnosed. Participants who have had rituximab in the last six months, or who have had any thromboses (clots) or are at a higher risk for thrombosis will also be excluded from participation.

China

https://www.clinicaltrials.gov/ct2/show/NCT04915482?recrs=a&cond=Immune+Thrombocytopenia&draw=2&rank=42

Recruiting

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