Platelet E-News: April 27, 2011

This e-newsletter is a monthly publication of the Platelet Disorder Support Association. The information in this newsletter is for educational purposes only. For advice on your unique medical condition, please consult a health care professional.

Contents:

ITP and Platelet Disorders Research and Treatments

Hospitals, Insurance, and Medical Care

General Health and Medicine

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ITP and Platelet Disorders Research and Treatments

 

ELTROMBOPAG INTERACTS WITH STATINS

Rosuvastatin (Crestor) is a statin drug frequently prescribed to reduce cholesterol. In a study of healthy volunteers who took both eltrombopag and Crestor, researchers found the concentration of Crestor in the blood was higher for those taking the combination compared to those taking Crestor alone. The authors conclude that someone taking both eltrombopag and any statin, since they work in a similar manner, may need a reduced dose of the statin to avoid increased side effects.

Allred AJ et al. “Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers.” Br. J Clin Pharmacol. 2011 Mar 25. doi: 10.1111/j.1365-2125
http://www.ncbi.nlm.nih.gov/pubmed/21434975

 

 

BEWARE OF COUNTERFEIT NPLATE

An unauthorized company is marketing a counterfeit version of romiplostim (Nplate®) via the Internet. The only way to safely and legally receive Nplate® in the US is through the FDA-sanctioned Amgen program, NPlate NEXUS. The doctors on PDSA’s medical board emphasize that any medications ordered via the Internet can be potentially dangerous. Patients are advised to tell their doctors if they are taking medications obtained in this manner and to report any side effects from them.

For information on the NEXUS program see:
http://www.nplate.com/patient/different_approach/nplate_nexus_program.html

 

 

LONG-TERM ITP OUTCOMES CALCULATED

After matching the age, gender, and co-morbidity status of 407 people with primary chronic ITP and 4,069 people without the disease, Danish researchers followed their subjects’ health status for about 5 years. They found the people diagnosed with ITP had a “substantially increased long-term risk of infections, hemorrhagic episodes requiring hospitalization, hematologic malignancies, and mortality,” than the control population. Those with ITP more than 60 years of age were at greater risk for problems.

Nørgaard M et al. “Long-term clinical outcomes of patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study.” Blood. 2011 Mar 31;117 (13):3514-20.
http://www.ncbi.nlm.nih.gov/pubmed/21263148

 

 

PLATELETS PLAY A ROLE IN THE IMMUNE SYSTEM

Platelets perform a key role in the immune system in addition to their more familiar job of halting bleeding. They can promote inflammation, help regulate your innate immune system (the one you were born with), and interact directly with microorganisms such as viruses. Because they are the first to reach the scene of a wound, they are well positioned to direct the body’s response to bacterial infections. Platelets can interact with bacteria directly or through various proteins circulating in the blood.

Cox D et al. “Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation.” J Thromb Haemost. 2011 Mar 21. doi: 10.1111/j.1538-7836.2011.04264.x.
http://www.ncbi.nlm.nih.gov/pubmed/21435167

Semple JW et al. “Platelets and innate immunity.” Cell Mol Life Sci. 2010 Feb;67 (4):499-511.
http://www.ncbi.nlm.nih.gov/pubmed/20016997

 

 

 

Hospitals, Insurance, and Medical Care

 

FDA PUBLISHES NEW WEB SITE FOR CONSUMERS

The Food and Drug Administration (FDA) launched a new Web site to make it easier for consumers to learn about product recalls. The Web site clarifies whether the recall is mandatory or voluntary, on-going or complete. The FDA also sends periodic e-mails on a variety of consumer-related topics for those who register. The new recall Web site is located at:
http://www.fda.gov/Safety/Recalls/ucm2005683.htm

To receive periodic e-mails from the FDA on the topics of your choice see:
http://www.fda.gov/AboutFDA/ContactFDA/StayInformed/GetEmailUpdates/default.htm

 

 

EXPANDED CALORIE AND NUTRITIONAL LABELING PROPOSED

Restaurants with more than 20 locations and businesses owning or operating more than 20 vending machines will be required to post the calorie count and nutritional information for some products according to the Affordable Healthcare Act. In compliance with that law, the FDA has published proposed rules detailing the restaurant and vending machine labeling requirements. These rules are open for public comment.

http://www.fda.gov/Food/LabelingNutrition/ucm217762.htm

 

 

 

General Health and Medicine

 

BACTERIA, YEAST, AND PARASITES FOUND IN BEACH SAND

To help create a healthier beach environment, researchers from the University of Miami measured various pathogens at different spots on a Florida beach, located some distance from any obvious source of pollution. They found parasitic worms, candida yeast, and bacteria, including penicillin-resistant S. aureus at their selected beach, with wet sand containing more pathogens than dry. The researchers also identified some markers that will make it easier to determine the amount of beach pollution without extensive testing.

Shah AH et al. “Indicator microbes correlate with pathogenic bacteria, yeast, and helminthes in sand at a subtropical recreational beach site.”J Appl Microbiol. 2011 Mar 29. doi: 10.1111/j.1365-2672.2011.05013.x
http://www.ncbi.nlm.nih.gov/pubmed/21447014

 

 

CELL PHONE RADIATION LEVELS PUBLISHED

The Federal Communications Commission limits the amount of radiation emitted by cell phones to the Specific Absorption Rate (SAR) of 1.6 watts per kilogram. To help consumers, several organizations have published a list of the SAR levels of individual cell phone makes and models. While the cell phone emits microwaves, not the x-ray type of radiation, the health consequences of cell phone radiation remain unclear. You can reduce the amount of cell phone radiation exposure by limiting use, using special cases, keeping the phone away from your body, and texting instead of calling.

Lee N, et al. “Cell phone radiation levels.” CNET Reviews, February 4, 2011.
http://reviews.cnet.com/cell-phone-radiation-levels/

Fortner M. “Cell phones' radiation levels ranked.” The NewsObserver, March 1, 2011.
http://www.newsobserver.com/2011/03/01/1021553/cell-phones-radiation-levels-ranked.html

http://www.fcc.gov/cgb/sar/

 

 

FRESH FOOD REMOVES BPA FROM BODY

According to the Centers for Disease Control, more than 90% of people have detectable levels of BPA (bisphenol A), a chemical used to harden plastics that is linked to a number of health problems. The amount of BPA and DEHP, another plasticizer, was reduced by more than half in only three days in a study of 20 people who switched from canned and plastic-wrapped food to fresh food. Their chemical levels returned when they resumed their prior packaged-food eating habit.

Forer B. “Study: Eating Fresh Food Reduces Exposure to BPA.” ABC News, March 30, 2011
http://abcnews.go.com/Health/study-reduce-bpa-exposure-cutting-consumption-packaged-foods/story?id=13256098

 

 

 

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This e-newsletter is published by the Platelet Disorder Support Association, 133 Rollins Avenue, Suite 5, Rockville, MD 20852, phone 1-87-Platelet, fax: 301-770-6638, web: www.pdsa.org, e-mail: pdsa@pdsa.org

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