Platelet E-News – April 17, 2004

Contents:

  • Effect of anti-CD154 on ITP
  • Questioning the role of positive thinking
  • Viagra and other cGMP stimulators interfere with platelet function
  • Diesel fumes suppress immune response
  • Several autoimmune diseases share one bad actor
  • IVIG Preparations not created equal
  • Will WinRho SDF® give you a fast, long-lasting response? (advertisement)
  • Herbal Treatment (advertisement)

 

EFFECT OF ANTI-CD154 ON ITP

Researchers in Japan treated twenty ITP patients with escalating doses of an experimental monoclonal antibody that blocks the CD40/CD154 signal. An increase in platelets was seen in three of the five subjects who received 10 mg/kg, the largest dose tested. CD40 on the antigen-presenting cells triggers CD154 (also known as CD40 ligand) on T-cells. Blocking the interaction between these cells is thought to interfere with the antibody production that takes place in autoimmune diseases. This compound is currently being used in clinical studies for various autoimmune diseases. Further studies are necessary to confirm the benefit of anti-CD154 in ITP patients.

“Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thromocytopenic purpura” Blood, 15 February, 2004 Vol 104, No. 4

http://www.bloodjournal.org

QUESTIONING THE ROLE OF POSITIVE THINKING

Encouraging positive thinking when the patient is a natural grouch can lead to unhealthy stress and a decrease in healing response reports Jimmie Holland at Memorial Sloan-Kettering. Patients who stay with their natural coping style rather that striving for a happy disposition have lower cortisol rhythms and natural killer cell counts, measures of stress and immune response.

“Fighting Cancer with a Frown:Research Questions Role of Optimism in Beating the Disease;’the Tyrrany of Positive Thinking’” A.D. Marcus, Wall Street Journal April 6, 2004

VIAGRA AND OTHER cGMP STIMULATORS INTERFERE WITH PLATELET FUNCTION

Drugs such as Viagra and other less common compounds increase cGMP, a chemical messenger that causes smooth muscles to relax and also interferes with the action of platelets. The new findings revise previous research that suggested increased cGMP lead to increased blood clots.

“Does cGMP mediate platelet inhibition or stimulation?” Wolfgang Siess,Blood, 1 April 2004, Vol. 103, No. 7, p. 2435

DIESEL FUMES SUPPRESS IMMUNE RESPONSE

Lower levels of exposure to soot particles from diesel exhaust over time reduce the immune system’s capacity to fend off infection more than the same exposure concentrated at one time. A follow-up study by Joseph K. H. Ma of West Virginia University and his colleagues exposed rats to the same level of diesel-derived particles as administered in earlier work but spread the exposure over 5 consecutive days. In this extended exposure, more bacteria survived in the lungs of diesel-exposed animals than in rats that breathed clean air.

“Diesel fumes suppress immune response” Science News, March 13, 2004, p. 174.

SEVERAL AUTOIMMUNE DISEASES SHARE ONE BAD ACTOR

Psoriasis, rheumatoid arthritis, and lupus, three distinct diseases, may share the irregular behavior of the same molecule. Three different research efforts have recently reported that these three different disorders seem to be controlled by the same protein, RUNX1 or runt-related transcription factor 1. This work may not quickly lead to new treatments but it does mean that research efforts that have been loosely connected can now converge on a common molecular target.

B. Harder, “All Roads Lead To RUNX”, Science News, April 3, 2004, p216-217.

IVIG PREPARATIONS NOT CREATED EQUAL

IVIG (IGIV, Gammaglobulin, IgG) infusions have a long and successful history in treating a wide variety of illnesses including ITP. However there are small but significant differences in the preparations from different manufacturers that can make a difference in the product’s safety and the likelihood of adverse effects. The best way to minimize adverse reactions is to match product characteristics such as osmolarity, sodium content, sugar content, IgA content and pH, among others, with patient profiles. Osmolarity (associated with thrombotic complications) and sodium content have implications for patients with CHF, renal dysfunction, neonates, the elderly, and patients with hypertension and vascular disease. The sucrose in sugar containing preparations has been associated with renal failure.

R. Sacher, “Not all IGIV Preparations Are Created Equal”, Hem/Onc Today, March 2004, pp. 5ff.
http://www.hemonctoday.com/200403/igiv.asp

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