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Fostamatinib for the Treatment of Adult Persistent and Chronic ITP...

Fostamatinib for the Treatment of Adult Persistent and Chronic ITP...

Results of Two Phase 3, Randomized, Placebo‐Controlled Trials

"The primary endpoint was stable response (platelets ≥50,000/μL at ≥4 of 6 biweekly visits, weeks 14‐24, without rescue therapy). Baseline median platelet count was 16,000/μL; median duration of ITP was 8.5 years. Stable responses occurred in 18% of patients on fostamatinib vs. 2% on placebo (P=0.0003). Overall responses (defined retrospectively as ≥1 platelet count ≥50,000/μL within the first 12 weeks on treatment) occurred in 43% of patients on fostamatinib vs. 14% on placebo (P=0.0006). Median time to response was 15 days (on 100mg bid), and 83% responded within 8 weeks."

- From Wiley Online Library

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