Search Results (Searched for: amox)

  • amberyard
12 Apr 2013 13:09
Helicobacter pylori and ITP was created by amberyard
Has anyone had H-pylori with ITP, I have all the symptoms. When I take ab's and antacids the pain goes away. Every where I have read 10-14 on med's twice daily. But some places say Amoxicillin can drop platelets? Just asking before I go to the doctor to get blood work done to see if I have it.

Thanks
  • Sandi
12 Apr 2013 15:03
Replied by Sandi on topic Helicobacter pylori and ITP
Amber:

Any antibiotic can cause counts to drop. I have, however, had counts drop twice from Amoxicilin and never from any other antibiotic. Some antibiotics can also cause counts to go up for some people, including Amoxicillin.

I'm pretty sure they can switch out the antibiotic if you're worried about it. I'd cross that bridge if you come to it after testing. You could just have GERD. I do.
  • amberyard
26 Apr 2013 15:14
Replied by amberyard on topic Helicobacter pylori and ITP
I had a GI problem on Amoxicilin so I can put that on the list of meds I can't take.
  • jpetrosky
04 May 2013 00:16
IVIG was created by jpetrosky
Hi all,

My name is Jordan, and this past month I was admitted twice to my local hospital for low platelet counts. My first visit they were down around 10K and they diagnosed it as an autoimmune reaction to EBV (Mono), which was initially misdiagnosed as a bacterial infection, and prescribed amoxicillin (which itself has a negative reaction with EBV, and one I encountered). Initially they introduced me to an 80 mg injection of dexamethasone, and watched as my platelets rose to about 35K. They released me on a tapered dose of prednisone. After finishing the course my platelets dropped again, this time to 4K. They decided against a transfusion as I wasn't showing signs of bleeding (just some small bruises). The administered dexamethasone once again raising my platelets to around 70K. Now I am on 75 mg dose of prednisone a day, but my CBC's have show a slow drop in platelets over the past two weeks. They are currently around 43K. They still think its being caused by EBV, but they're not ruling out ITP.

One question I have is whether or not there is any additional ways for me to suppress my immune system to keep my anti-platelet antibodies down?

Second question is, is that they are discussing starting a IVIG treatment, and was wondering if anyone has any experience with it? What its effectiveness is, what are the side effects, and how long do the treatments take?

Thank you all for your time.

Cheers,

Jordan Petrosky
04 Jun 2013 12:41
Replied by on topic New Diagnosis
Too funny about your husband!

You are like me - I can do it myself. Years ago when I had serum sickness from amoxicillin [didn't know what it was though - only that the pain was extreme and my knees and feet were so swollen & red & hot & very very painful] that Saturday morning I told my husband to keep our plans of taking the boys skiing and spending the night, I didn't want to ruin their fun so I sent them off then drove myself to the ER.
  • Sandi
16 Jul 2013 17:49 - 16 Jul 2013 18:41
Replied by Sandi on topic Avoiding drug-induced thrombocytopenia
Rob:

I assume you mean me? Ha. Well, this is the way I feel about it.

If you take a good look at a lot of the drugs used to treat ITP, you will find that thrombocytopenia can be a side effect. Go figure. So knowing that, if you take a good look at most other drugs, you will see that thrombocytopenia is also listed quite often. In fact, it's difficult to find a drug that doesn't list it. Going through a general list of common side effects is not enough. You have to look at a PDR or a source that has specifics.

The first year that I was diagnosed, I was really paranoid about taking anything that might drop my counts. It happened twice with Amoxicillin. The first time I chalked it up to coincidence, but the second time I decided to just stay away from it. Many people here have taken Amoxicillin with no problem. Anyway, everyone knows to stay away from aspirin and NSAID's because doctors warn about it. When Tylenol got added to that list, I gave up and decided to just take what I want as long as my counts were above 50k. A lot of the meds don't necessarily cause counts to drop, but they can thin the blood which isn't good if counts are down. So I threw caution to the wind and started taking Naproxen because I needed it for another medical issue. Nothing bad happened. Then I got another diagnosis and had to start aspirin and some other ITP contraindicated drugs. Again, nothing bad happened.

Sometimes there just isn't a choice in the matter. Sometimes, you have to treat other, potentially serious medical issues, even if it means counts might drop. I have seen some people who refuse to treat other problems because of the fear of a relapse. I know what it takes to achieve a remission; I know how hard that can be. But to ignore another problem due to that fear is just silly. Some people are so afraid of antibiotics dropping counts that they won't take them. Well, the infection could also cause counts to drop too so which is worse? To ask a doctor to find one that won't drop counts is nearly impossible. No one knows how any individual will react to a particular drug. No one can give you that guarantee. If thrombocytopenia is not found on a list, that doesn't mean that it won't happen anyway. The list of side effects is only that; a list that contains reported side effects. If it hasn't been reported, it won't be on the list. Many side effects go unreported because doctors either don't report it or the connection of the drug to the side effect is never made. I'm sure the risk of a count drop is more common with some drugs than others, but just because it can does not mean that it will.

You could scour the list of side effects for a drug and not find ITP. But most people completely ignore side effects like TTP, Steven Johnson Syndrome, Guillain Barre, etc. Those are very scary, potentially fatal side effects. I'd take ITP over those any day.

Okay, having said all of that, there are lists if you are still serious about sticking to one. Unfortunately, I really think that it is basically trial and error when it comes to any drug. This list is a good place to start.

pdsa.org/about-itp/warnings.html

How's that for an answer? A bit long-winded.... :huh:
  • Sandi
09 Sep 2013 16:04 - 09 Sep 2013 16:05
Roberta:

It's much easier to provide a list of drugs that may not be okay. There are hundreds, if not thousands of different antibiotics. The problem is that one person might have a problem with a certain antibiotic and another person may not have a problem.

I have had counts drop twice from Amoxicillin while others here have done fine or had counts go up. It could have been a coincidence; I will never know for sure.

You never know how anyone will react to a medication. I think I've said this before, but almost every medication lists thrombocytopenia as a side effect, even the drugs used to treat ITP. The side effects that I get from meds these days keep getting worse as time goes on. To tell you the truth, I don't even fear ITP; I fear Steven-Johnson Syndrome, TTP, Guillain Barre, etc. which are potentially fatal or debilitating.

There is no list of antibiotics that are "okay", but there is a comprehensive list of drugs that are known to possibly cause thrombocytopenia. Just because it can does not mean that it will, and if it's not on the list, that does not mean that it won't affect you. Good luck!

www.ouhsc.edu/platelets/InternetPostingLitGroup2_18_11.htm
  • Christine
16 Oct 2013 20:33
Replied by Christine on topic Dental work with low platelets?
Good communication between your hemo and your dentist is important. My dentist makes me take pre meds (amoxcillin - sp) before every appointment (my counts are usually in mid 30s and I'm on N Plate) I have recently had quite a bit of dental work done - the details are on Social Chat titled "My Saga" If you have any questions - don't hesitate to ask. BTW I still look like a Jack O'Lantern/Scary Granma. Things have been delayed because of our Thanksgiving.
High Platelets, Christine :)
  • Sandi
07 Feb 2014 09:45
Replied by Sandi on topic Antibiotics In ITP Patients
Everyone is different. Some people find that their counts go up with a certain antibiotic and some people experience a drop. My counts dropped twice due to Amoxicillin but have gone up with other antibiotics. For some people, antibiotics don't affect counts at all.
  • stevenkalb
22 Mar 2014 18:07
I"m newly diagnosed with ITP - seeing a doc who is probably first rate but I don't really connect with him

I'm looking for recommendations for a someone who practices in Santa Monica or Westwood CA, who is a smartest guy/gal in the room and also has good communication skills

Some pertinent info is below.

If anyone has anything to add I'd much appreciate it.

Thanks to all!

+++++++++++++++++++++++++++++++++++++++++++

I'm 68 years old -

Starting in late 09 my platelet count dipped into the low 100's

Starting in Autumn of 13 it dipped into the high 50's

Since then counts taken every 10 weeks or so have been 57, 46, 53, 56, 35, 44

I'm intolerant of steroids - in 03 I took Medrol for a bulging disc in my neck, and it laid me so low I had to abandon it after the 4th day.

My current doc wants me to start I think it's Rituxin - 4 treatments, 4 hours per treatment with an IV drip (Does that sound like Rituxin?)

I'd like a second opinion before I start strong meds

Some other info that may or may not mean anything to having a low platelet count

++++++++++++++++++++++++++++++++++++

I had two knee replacements in Dec 08, and Dec 09

Late in 09 my Platelet count dipped from normal range into the low 100's and stayed there - give or take 20 points

March 2013 I took my first trip to the far east - Hong Kong and Phuket

April 2013 I developed fierce vertigo - went to several docs but no one could diagnose the cause

The severity of the vertigo lessened gradually but never went away

Dec 2013 I got a gum infection from a teeth cleaning, took a 7 day course of amoxicillan, the infection was cured and the vertigo disappeared along with it
  • Ann
20 May 2014 14:42

Melinda wrote: Ann what is the testing for penicillin allergy? I'm allergic to it but my allergy is fairly new so I can't have it - and believe me with the serum sickness I had from it I don't ever care to have it again!


The allergy testing was done by injecting tiny bits of different diluted penicillins under the skin on the forearm, along with controls of water and an antihistamine. So about six skin injections in a line. The antihistamine itched like anything but we weren't allowed to scratch! Then an hour later doing it again with less diluted samples, and so on each hour until it was at full strength. Then if no reaction, giving diluted amoxycillin by mouth, and repeating each hour with less diluted stuff. I don't remember how many times they did it all but it went on all day. I wasn't alone thank goodness as three of us were being tested at the same time.

The doctor doing it said that he'd done loads and very, very rarely does anyone show an allergy.
20 May 2014 16:23
Thanks Ann! To me that is scary since it was amoxicillin that caused my serum sickness. Will have to give this some thought as to whether I should ask to be tested.

Ghost, you are "special' ;)
  • Sandi
04 Jun 2014 16:18
Unless someone has a platelet count done, it is hard to know if a person has low platelets or not. Nose bleeds can be a symptom, but can also be caused by dry weather or a vessel that needs cauterized. It's fairly common. If you did have lower than normal platelets for a long time but were not bruising badly, covered in petechiae or experiencing other bleeding, then it obviously wasn't a problem.

Both an illness or an antibiotic, or the combination of both, could possibly trigger ITP. Many drugs have the potential to trigger platelet drops and everyone is different as to what drugs cause a problem for them. I've had platelet drops twice due to Amoxicillin but have also taken it years later and platelets were fine.

As for coming off of N-Plate, how low do your counts drop when you skip a dose? It is common for counts to bottom out when a dose is missed. That is stated on the manufacturer's website. Have you ever been able to maintain a count between 30 and 70 on N-Plate for a period of time? If so, then that is the goal with N-Plate and you hit on a good dose for you. The dose should be adjusted to maintain counts for a while before trying to stop or miss doses. Some people do achieve remission but some do not. ITP does not always self-correct and sometimes it can take years to get to that point.

What side effects are associated with Nplate®?

Nplate® can cause serious side effects:

Worsening of a precancerous blood condition to a blood cancer (leukemia)
Higher risk for blood clots
Bone marrow changes (increased reticulin and possible bone marrow fibrosis)
Worsening low blood platelet count (thrombocytopenia) and risk of bleeding shortly after stopping Nplate®
Lack or loss of response


Will Nplate® raise my platelet count to normal levels?

No, Nplate® is not intended to make your platelet count normal. Treatment with Nplate® is intended to keep your platelet count at about 50,000 per microliter, a level that lowers the risk for bleeding.

www.nplate.com/patient/nplate-patient-support/faq.html#why
11 Oct 2014 19:48
HaveitAll anyone can get serum sickness to any medication - I do not have lupus and I have never had rituxan, however I had serum sickness to amoxicillin

MedlinePlus is where I like to get information - here's what is said about serum sickness:

www.nlm.nih.gov/medlineplus/ency/article/000820.htm
23 Nov 2014 14:05 - 23 Nov 2014 14:07
Replied by on topic FLU SHOTS
My ditzy PCP whom I fired in October 2013 would always tell me I needed the shingles vaccine - this was after I was told no vaccines, but I would just look at him and tell him I have ITP and cannot have live vaccines. He'd say oh - then the next time I'd be in he'd tell me I needed the shingles vaccine and on and on. So glad to be rid of him!

What a ditz that doctor is who handed you the list and said Rituxan isn't on it so can't cause serum sickness. Wish you had that list still, I'd like to know if amoxicillin is on it or if I just was making up all those horrendous side effects that were attacking me thanks to it causing serum sickness. It is like the ditzy doctor who told me gamma globulin cannot trigger ITP but vaccines can - huh??!! Hematologist I had back then has it in my records that it did most likely trigger mine.

Sandi one of those doctors is my dear dear dear hematologist who passed away this month.
  • brizee
13 Jan 2015 20:21
Replied by brizee on topic Example: Advocating for the care YOU want
How long before your ITP Dx did you take the antibiotic? I filled a script for amoxicillin on 8/15, came down with ITP on 9/22.
  • Sandi
13 Jan 2015 20:39
Replied by Sandi on topic Example: Advocating for the care YOU want
Brizee:

The problem is that either an illness or the antibiotic used to treat it could trigger ITP. Sometimes it can be the combination; a cascade of events that disturbs/changes the immune system.

I was diagnosed with ITP after a bad cold, but had two major platelet drops twice after taking Amoxicillin. I stayed away from it for many years after that, but recently had to try it again since I am having worse reactions to other antibiotics. The last few times I used it, I had no problems.

Sometimes you can't make heads or tails out of 'cause' because the actual trigger might even be something that you didn't think of. Some people have been diagnosed after using supplements like Echinacea but they don't put two and two together because they think something was harmless. Come to think of it, I was using Echinacea around the same time that I had the bad cold, and Echinacea has been known to trigger autoimmune disorders.

It's possible that Amoxicillin triggered ITP, but you probably won't know for sure. Your counts may have started dropping slowly right after you began the drug and you didn't find out for a month, or it may not have been that at all. I'd try to avoid that family of drugs though, if possible.
  • Sandi
22 Jan 2015 13:50
Replied by Sandi on topic New articles posted here - update 6-28-17
Abstract

The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication as the first line treatment for persistent or chronic ITP patients with moderate thrombocytopenia. Patients with persistent or chronic ITP showing moderate thrombocytopenia (30 × 109/L ≤ platelet count ≤ 70 × 109/L) and positive C13-urea breath test (UBT) were selected. Medication consisted of lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg orally twice daily for a week. Complete response (CR) rate at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 50.0, 50.0, 26.9, and 65.4 %, respectively. Overall response rate (ORR) at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 57.7, 65.4, 30.8, and 69.2 %, respectively. Median maximal platelet count during the first 3 months was 110 × 109/L (range, 40-274). Median time to CR was 8 weeks (95 % CI = 5.429-10.571). Median time to ORR was 4 weeks (95 % CI = 1.228-6.772). Only per-protocol population was a response predictor for ORR at 3 months (70.0 %, p = 0.054) and maximal ORR (80.0 %, p = 0.051), but not for CR at 3 months (60.0 %, p = 0.160). Therefore, eradication of H. pylori is an effective and durable first line treatment for persistent or chronic ITP with moderate thrombocytopenia with high ORR and rapid onset in this study.

www.ncbi.nlm.nih.gov/pubmed/25501820
  • Ann
16 Feb 2015 08:45
Replied by Ann on topic CVID
Hi all,

My latest scores:

IgG 430
IgA 13
IgM 58

Still taking daily antibiotics of Septrin, and have amoxycillin on hand in case of ear infections. I got tested for penicillin allergy which was negative. I'm really pleased about that as it's a useful drug to have available.

I also get very tired and am thinking (again) of giving up work but have just moved house and have stuff to buy so will hold on for another couple of months as the salary is useful! I really want to work part-time but can't find a job I like with the right hours so I may just give up altogether and live off savings.
  • Sandi
15 Jun 2015 16:11
Replied by Sandi on topic Antibiotics
Any drug or any antibiotic could possibly drop counts. I've had drops twice from Amoxicillin, but was able to take it years later with no problems. Some antibiotics can also raise counts, so you just never know. At any rate, either the illness or the antibiotic used to treat it could cause a drop so it's a risk either way. Just do what you normally would for an infection and try not to worry about it. What happens, happens.
  • StanSand
16 Jun 2015 11:45
Replied by StanSand on topic Antibiotics
Just an update. I convinced my hematologist to try a low level antibiotic (250 mg amoxicillin 2xday) to see what happens. The rationale is that I had a splenectomy almost 20 years ago and was going to an under developed country (Cuba) so the antibiotic was a prophylaxis against infection. Also, I had been on amoxi for about a month previously as a test. So what was the net result... platelet count of 12,000 6 weeks ago to 406,000 yesterday. My theory is that I may have a chronic infection in the gut, not h pylori for which I tested negative, that stimulates an immune response against my platelets, and an antibiotic brings that under control. When one considers the enormous number of bacterial types present in the gut, in the billions, and only h pylori is tested for, it may not be an unreasonable hypothesis. Also, recently some colleagues (I teach engineering at a university) have sent me articles on antibiotic treatment of ITP in particular, and auto-immune diseases in general.
My point in posting this is to learn whether anyone else on the PDSA discussion group has seen similar variations in platelet count with antibiotics. Of course, long term antibiotic treatment may not be a good solution since it may give rise anti-biotic resistant bacteria that could be fatal.
18 Jun 2015 00:35
Replied by on topic Antibiotics
Having had serum sickness due to taking amoxicillin I was told not to take a penicillin again. From what I gather my reaction to sulfa was an unusual one.
  • Ann
10 Sep 2015 17:07
Replied by Ann on topic CVID
Hi, good to hear from you. I take daily antibiotics (co-trimoxazole) for prevention. It gives me no side effects at all. It's more usual here to take azithromycin three times a week for prevention but that gave me stomach issues so I asked to change. I have amoxicillin at home ready for those times when an infection takes off quickly so that I don't have to see a GP first. That is very useful although I haven't needed them for a few months now.

With the immunoglobulin I've been told it'll be IV every three weeks but I'd rather do weekly subcut at home as many others do, so I'm going to ask about that.

I recently gave up working full-time and took a different sort of job working just two days a week which is lovely. I'm loving five days off each week. I've only been there two months and was dreading having to take time off for chemo but seems that's not going to happen now so that's a big relief.
  • Sandi
12 Sep 2015 19:51
Replied by Sandi on topic Questions for Those Experienced with ITP
As far as I know, it's not possible to do that. They can do that for quinine because those are specific, identified antibodies that will always cause a serious platelet drop for individuals that are sensitive to quinine. As far as ITP and antibiotics, it does not occur that often and it just isn't done. Most people are not on antibiotics that often.

I have had drops twice due to Amoxicillin, or it could have been a coincidence. I stayed away from that antibiotic for about ten years. Then I needed one one day and my doctor said Amox would be the best one so I agreed. No platelet drop and I've used it a few times since. With ITP is is difficult to determine the difference between cause and coincidence.
  • markhudson
07 Nov 2015 14:18 - 07 Nov 2015 14:22
Replied by markhudson on topic To Splenectomy or not to splenectomy?

Sandi wrote: I don't know how the spleen can make things worse. That's an odd theory. People with normal spleens can get sepsis too. That's very scary. What happened that caused it?


The spleen destroys platelets, red cells and produces white cells. So they believe it is doing too much destruction and not enough production. My bone marrow shows that its doing everything it should. As for the sepsis they have no idea what the cause was as they hit me with Gent/Taz, Co-Amoxiclav and GCSF to fight it but abdo CT showed no signs of infection. Chest X-ray was clear and no obvious sign of infection else where. Both Aerobic and Anaerobic cultures came back negative (taken when fever of 39 C on three seperate occasions)

Ann wrote: So Mark, is your spleen enlarged? If so, that would add to the theory of hypersplenism, if not then they are just guessing. I don't envy you having to make this decision.


My spleen is 17.2cm and CT scan showed it was 'Bulky' (11cm is normal apparently) I have had three abdo CT so they have a clear idea on what it was before and it has got larger. My last 2 showed it enlarged and the first of those two was performed when i was healthy.
  • Ann
08 Nov 2015 06:04 - 08 Nov 2015 06:05
Replied by Ann on topic To Splenectomy or not to splenectomy?
I found that many sites on the internet simplify things far too much and end up being wrong. I don't mean Sandi's link, I haven't looked at it yet. I bought a haematology book when diagnosed with ITP which I dip into from time to time but it's all far too complicated to remember in detail.

From what I do remember white cells are made in the marrow with some going off to the thymus gland to be made into T cells which are CD4 and CD8s. The CD8s are Natural Killer cells and the ones that I lack (that's why I remember that). B cells go off from the marrow into the blood and to the spleen and the lymph nodes.

I looked up Castelemans not so long ago because I have an overgrowth of white cells in the lymph nodes, but it didn't fit for me. Among other things it is supposed to make the IGs high and mine are low. As you will have read, Castlemans can be not so bad or not so good depending on the sort.

Have you got antibiotics at home for emergencies? I have a stash of amoxycillin in addition to the Septrin I take every day. There's also the genome sequencing studies going on. Are your doctors taking part? My blood was sent off a year ago and still haven't heard back but still it might be useful eventually.
  • markhudson
08 Nov 2015 15:07
Replied by markhudson on topic To Splenectomy or not to splenectomy?

Ann wrote: I found that many sites on the internet simplify things far too much and end up being wrong. I don't mean Sandi's link, I haven't looked at it yet. I bought a haematology book when diagnosed with ITP which I dip into from time to time but it's all far too complicated to remember in detail.

From what I do remember white cells are made in the marrow with some going off to the thymus gland to be made into T cells which are CD4 and CD8s. The CD8s are Natural Killer cells and the ones that I lack (that's why I remember that). B cells go off from the marrow into the blood and to the spleen and the lymph nodes.

I looked up Castelemans not so long ago because I have an overgrowth of white cells in the lymph nodes, but it didn't fit for me. Among other things it is supposed to make the IGs high and mine are low. As you will have read, Castlemans can be not so bad or not so good depending on the sort.

Have you got antibiotics at home for emergencies? I have a stash of amoxycillin in addition to the Septrin I take every day. There's also the genome sequencing studies going on. Are your doctors taking part? My blood was sent off a year ago and still haven't heard back but still it might be useful eventually.


I don't have antibiotics beyond my septrin and I don't think my Dr's are in the genome sequencing study
30 Dec 2015 19:27 - 30 Dec 2015 19:27
Regarding serum sickness - I got it from amoxicillin. My reaction was very very swollen/red/hot extremely painful knees and ankles - and palms of my hands - I could hardly put one foot in front of the other to walk, but had to take myself to the ER as husband & sons were on a skiing trip.

I wouldn't think fear of serum sickness should stop someone from using Rituxan should it - if that is the case then people shouldn't take penicillins or any other med that has serum sickness as a reaction. However once someone has had serum sickness to a mediation that med should not be taken again. I now cannot have any penicillins.

www.nlm.nih.gov/medlineplus/ency/article/000820.htm
[this does mentions rituxan, also penicillin and sulfa]
"Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances."

"Symptoms usually do not develop until 7 to 21 days after the first dose of antiserum or exposure to the medication. However, some people may develop symptoms in 1 to 3 days if they have already been exposed to the substance."
  • momto3boys
31 Dec 2015 04:13
Replied by momto3boys on topic ITP "lifer" New Here and Seeking Treatment Advice

Melinda wrote: Regarding serum sickness - I got it from amoxicillin. My reaction was very very swollen/red/hot extremely painful knees and ankles - and palms of my hands - I could hardly put one foot in front of the other to walk, but had to take myself to the ER as husband & sons were on a skiing trip.

I wouldn't think fear of serum sickness should stop someone from using Rituxan should it - if that is the case then people shouldn't take penicillins or any other med that has serum sickness as a reaction. However once someone has had serum sickness to a mediation that med should not be taken again. I now cannot have any penicillins.

www.nlm.nih.gov/medlineplus/ency/article/000820.htm
[this does mentions rituxan, also penicillin and sulfa]
"Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances."

"Symptoms usually do not develop until 7 to 21 days after the first dose of antiserum or exposure to the medication. However, some people may develop symptoms in 1 to 3 days if they have already been exposed to the substance."


Thanks for helping with the serum sickness question. I think Rituxan has plenty of other aspects to scare me without the consideration of serum sickness, so my plans are heading in another direction.
  • Sandi
04 Jan 2016 21:11
Replied by Sandi on topic Antibiotics decreased my platelet count
Vanessa:

Antibiotics can cause drops is counts, but they can also cause rises. It all depends on the med and the person. Sometimes it's not the drug but the infection that causes the drop. In the past, I've had two drops after using Amoxicillin, but years later did not have any problems.

Try to stay calm. Bruises are not the end of the world. They are going to happen with ITP. Dex is probably contributing to your anxiety and you should speak to your doctor about an alternate way to manage this. I've never seen ITP managed with Dex that way. I've been around here for a very long time.
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