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Drosfemine + Revolade = higher risk of thrombosis? 1 year 2 months ago #69830

  • ImPatient
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My new gp just brought up it might be too risky for me to continue this particular birth control- Drosfemine- because he thinks in combination with Eltrombopag the risk for thrombosis is too high. I thought the reason why the risk is higher on birth control is that the amount of platelets might increase, whereas on Eltrombopag it's because of the bigger stickier ones... or does that happen on birth control too? I'm actually taking birth control because I get cysts without it, so I'm not sure what to do now. Hema say ask gynacologist, gynacologist says doesn't know about ITP... So if Drosfemine "only" causes too many platelets in some patients, that is not really the case for me anyway?
By the way I've been away a while, thrombos dropped to 50, then it was up between 140 and 160 the last weeks. We're thinking about lowering the dose of Revolade but not sure yet.

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Drosfemine + Revolade = higher risk of thrombosis? 1 year 2 months ago #69833

  • MelA
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I have no idea because I've never taken rovolade.
However ITP does not make one immune from a stroke. A lady in a group of ITPers who used to meet here in my town had a stroke and her platelet count stayed about 5,000.

I would think your gynecologist should take the initiative and look into the side effects of your birth control to see if it is safe for you to take and if not then what would be a safe alternative - actually I would want my hematologist and gynecologist to get together to discuss the matter.

Good luck!
"Instead of wasting your time worrying about symptoms, just get it checked out" -Nieca Goldberg, MD
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Drosfemine + Revolade = higher risk of thrombosis? 1 year 2 months ago #69834

  • mrsb04
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  • Diagnosis of ITP in 2014. Retired (Nov 2019) renal specialist nurse, 46 years on the NHS front line. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use
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I'd add in a pharmacist too. Personally if I was younger and in need of contraception I would not even consider using an oral method whilst taking Eltrombopag.
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Drosfemine + Revolade = higher risk of thrombosis? 1 year 1 month ago #69870

  • ImPatient
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Thank you you two. I haven't had any luck with the doctors, they don't know. I don't really use birth control as contraception at the moment, I started taking it against ovarian cysts after I needed to have surgery for it. That was two years ago. I'm 40 and still fertile but not planning on dating anyone anytime soon. I'm guessing there's not much more one can say about it, except for a doctor who might know... So my decision is I'll keep taking both, because I haven't had a problem so far and I'd be afraid of messing with my hormones unnecessarily...

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Drosfemine + Revolade = higher risk of thrombosis? 1 year 1 month ago #69871

  • ImPatient
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On us.promacta.com it says "If you are a woman who is able to become pregnant, you must use reliable birth control (contraception) while taking PROMACTA and for at least 7 days after you stop taking PROMACTA."
So it seems other women take birth control with it. Maybe one that has a lower risk though.

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Drosfemine + Revolade = higher risk of thrombosis? 1 year 1 month ago #69941

  • SusanMichelle28
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  • I was diagnosed with ITP in March 2012. I've tried almost every treatment under the sun. Nothing really works without creating a new issue. Just taking it all one day at a time!
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While I cannot comment on the clotting with Eltrombopag and birth control I can comment on Eltrombopag and prednisone (at the time I had a HORRID hematologist and he had me on both when it specifically states not to do that). While taking both medications I developed severe Pulmonary Emboli. It really put a kink in my ITP treatment.
My (new) hematologist will not even consider Eltrombopag any longer because of its being prone to causing clots with me. He stated somewhat the same as your doctor. It will cause a release of platelets into the system before they are mature enough; they'll be too big and too sticky.
Prednisone and Birth Control are VASTLY different medications, however, they may act similarly in regards to clotting when in combination with Eltrombopag.
Just wanted to give a perspective from someone that did develop clots on the Eltrombopag.

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Drosfemine + Revolade = higher risk of thrombosis? 1 year 1 month ago #69963

  • ImPatient
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Hi Susan, Thanks for your feedback and I'm sorry to hear you had bad experiences with Promacta & Prednisone. I can relate to some hematologists not making the best choices. I had severe chest pain and trouble breathing on NPlate when my doctor at the time wanted to actually overdose it, I had a one hour discussion about this nonsense, then left the office and never came back. Well... right now 25mg Promacta are enough for me, in fact my counts have been quite high most of the time, so we'll see if we'll make any changes in the dose sometime...

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