I was actually taking NAC along with some other supplements, by naturopathic doctors orders, and at that time my platelets were creeping up. I've since stopped and they're back down in the 60's. I have no clue if it was related, but I do intend to try it again and see if it helps. I don't know if you're not supposed to take it as one other person responded here, but I've made doctors aware and haven't been told not to. Have you since heard anything else on NAC?
Coincidentally or not, I restarted taking NAC after I found out that I had a tooth 'resorption' problem with one tooth. It seems to have helped A LOT with that. If one looks up 'NAC osteoporosis' that will get you started on that subject, if interested.
- The articles posit that oxidative stress is linked to the development of ITP.
- The article says that oxidized glutathione (GSH/GSSG) represents a good marker of your oxidative stress status,
- NAC when consumed, NAC gets absorbed in the gastrointestinal tract, sent to the liver, and converted to cysteine. The liver uses cysteine to produce glutathione.
The oxidative stress idea makes a lot of sense from my personal experience.
I don't know anything about NAC supplementation, but just wanted to make clear that the second two articles you linked from ashclinicalnews and springer.com all refer to TTP (Thrombotic Thrombocytopenia Purpura) and not ITP. I didn't read the first one, but just wanted to throw it out there that TTP is a different condition.
There are now actually studies underway looking treating ITP with NAC + Dexamethasone. It will be interesting to see what the results. It would be interesting to see studies done on keeping people in remission by supplementation of things which attenuate the immune system and reduce oxidative stress. I get the feeling my ITP relapses for example is brought on by just having a lot of things to deal with and the immune system going haywire.
NAC already has good evidence for supplementation in the winter months to reducing the length and severity of infections. Vitamin D is similar. It would be great to see more studies on both.
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