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TOPIC: Th1/Th2 dominance disorder

Th1/Th2 dominance disorder 2 years 9 months ago #58727

  • poseymint
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I thought this article was interesting. I don't completely understand how it applies to ITP. ? Perhaps we could swing either way since ITP can have many factors working to lower platelets- any comments? Oh, just read under "Warnings" that green tea inhibits platelet function, well that answers that part.

www.precisionnutrition.com/rr-green-tea-hazards
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Th1/Th2 dominance disorder 2 years 9 months ago #58732

  • Hal9000
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Posey. In my interest to become a doctor, errr ahhh I mean, in my interest to understand ITP, this article was fantastic. Some questions.

- I searched for the word 'platelet' and found nothing. Same with the word 'warnings'.
- Having trouble with this sentence. "For example, during pregnancy women have a tendency to shift towards a Th2 dominance, which is advantageous since a Th1 shift would induce rejection of the fetus." Why would a Th1 shift induce rejection of a fetus? Is it because a Th1 shift causes immune system attacks on larger invader organisms? Th2 (B cell antibodies) for small organisms like viral bacteria?
- Is ITP a Th1 or a Th2 dominant disorder? This article suggests that it is Th1 dominant. How can that be? Obviously platelets are very small so Th2 dominant would make more sense.
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Th1/Th2 dominance disorder 2 years 9 months ago #58734

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Thanks for your response Hal! I should have been more clear. I originally was reading about the benefits of green tea. But then read this article about how with an auto-immune disorder green tea might be harmful. Regarding my mention of "Warnings". I meant in the PDSA website there is a section called "about ITP" and under that heading, there is a page called "warnings". It lists foods that might inhibit platelet function. And green tea is listed- so I could have gotten my answer from the PDSA website.

I don't understand this idea of Th1/Th2 (thing one and thing two? from the cat in the hat?) So just wanted to put it out there.
ps Actually, I just googled further about this- I don't see any scientific articles on it or science behind it. Possibly just an idea someone has come up with.
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Th1/Th2 dominance disorder 2 years 9 months ago #58737

  • Hal9000
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Looked into this some more Posey. According to this 2003 paper , the Th1/Th2 balance was an idea popular in the late '90s. But apparently the notion is too simplistic to fully describe the intricacies of the immune system when applied to various diseases.

Still, the article was really good. It described all the different immune cell types in an easy to understand manor. Thanks.
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