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Acid reducers linked to kidney disease 5 years 8 months ago #54200

  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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Many of us use these drugs. I did too, but realized I could pretty much control acid reflux with a major diet change. It went from severe to mild. I am so over taking pills for everything, they are just causing more damage.

www.washingtonpost.com/news/to-your-health/wp/2016/01/11/popular-heartburn-medication-linked-to-chronic-kidney-disease/

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Acid reducers linked to kidney disease 5 years 8 months ago #54203

  • Aoi
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Nice find. I've been encouraging several family members and friends to make the dietary changes to reduce/resolve their GERD so they could stop taking PPIs. The evidence for problems with bone health and B12 deficiency was enough in my view to justify dietary/lifestyle approaches over taking PPIs.

Glad to hear you're making progress on reducing medication use.

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Acid reducers linked to kidney disease 5 years 8 months ago #54207

  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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Cutting out caffeine was a big help. No chocolate or spicy foods either.

I have totally overhauled my thinking as far as drugs go. You listed B-12 deficiency and bone health as potential side effects and old Sandi would have said, "I'll just take B-12 and calcium". Nope, I'm done destroying my body with all of these drugs. I know that I need some of them for now, but I'm off of the drug Merry-Go-Round because one just leads to another. Drugs don't cure, they keep you sick. Granted, they are needed at times but we are WAY over-prescribed in this society.

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Acid reducers linked to kidney disease 5 years 8 months ago #54208

  • TerriC14
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I could not agree with you more Sandi. This proves the point well, a class of drugs which you would percive to be relatively mild and brings relief to a very uncomfortable problem. But the reality is that the majority of drugs have some side effects, many which are discovered after prolonged use. We all know of the isde effects of something like steroids, but are uniformed about the side effects of meds we believe to be mild. Then you take more pills to counteract the side effects and up with shopping bags full of meds...

As I have stated before I am not anti medicine but I would use the lowest amount possible to get the desired results, and if a lifestyle change could substitute for medication therapy it would be worth a try. I commend you for taking control through lifestyle changes.

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Acid reducers linked to kidney disease 5 years 8 months ago #54226

  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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I took that acid reducer, Acifex, without much thought. It wasn't really working though, so I asked my GP to raise the dose. I realized that I was on a very low dose. She refused and said there are too many side effects. I'd always thought it to be an innocuous medication and thought her statement was odd, so I looked it up. I had been using it long and would have used it long-term. Here is the list:

Oncologic

Any drug which increases gastric pH would be anticipated to stimulate release of gastrin. Animal studies have demonstrated an increase in plasma gastrin concentrations following the administration of rabeprazole (the active ingredient contained in Aciphex) In addition, lifelong high-dose animal studies have revealed a dose-related increase in the incidence of gastric enterochromaffin-like (ECL) cell carcinoids (especially in female rats). However, to date, human studies of up to 1 year have not found any suggestion of gastric carcinoid formation due to rabeprazole use.

Oncologic side effects have not been reported.

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, abdominal pain, vomiting, dyspepsia, flatulence, constipation, dry mouth, eructation, gastroenteritis, rectal hemorrhage, melena, anorexia, cholelithiasis, mouth ulceration, stomatitis, dysphagia, gingivitis, cholecystitis, increased appetite, abnormal stools, colitis, and esophagitis. Rarely, cholangitis, duodenitis, salivary gland enlargement, and thirst have also been reported.[Ref]

Nervous system

Nervous system side effects have included headache (2.4%), insomnia, anxiety, dizziness, depression, nervousness, somnolence, hypertonia, neuralgia, vertigo, convulsion, abnormal dreams, decreased libido, neuropathy, and tremor. Agitation, amnesia, confusion, extrapyramidal syndrome, and hyperkinesia have rarely been reported. Hand and facial numbness have also been reported.[Ref]

Endocrine

Endocrine side effects have included gynecomastia, breast enlargement in females, and breast tenderness.[Ref]

Dermatologic

Dermatologic side effects have included rash, pruritus, sweating, urticaria, photosensitivity, and alopecia. Rare reports of dry skin, psoriasis, and skin discoloration have also been reported.[Ref]

Hepatic

Hepatic side effects have included rare cases of hepatic encephalopathy, hepatitis, hepatoma, and fatty deposits in liver.[Ref]

Respiratory

Respiratory side effects have included dyspnea, asthma, epistaxis, laryngitis, hiccup, and hyperventilation. Rare reports of apnea and hypoventilation have also been reported.[Ref]

Genitourinary

Genitourinary side effects have included cystitis, urinary frequency, dysmenorrhea, and dysuria. Rare reports of impotence, hematuria, orchitis, and urinary incontinence have also been reported.[Ref]

Cardiovascular

Cardiovascular side effects have included rare reports of angina, tachycardia, sinus bradycardia, palpitations, hypertension, myocardial infarction, syncope, angina pectoris, bundle branch block, palpitations, supraventricular tachycardia, and peripheral edema. Electrocardiogram abnormalities have also been reported.[Ref]

Hematologic

Hematologic side effects have included rare reports of anemia, ecchymosis, lymphadenopathy, and hypochromic anemia.[Ref]

Hypersensitivity

Hypersensitivity side effects have included fever, allergic reaction, chills, malaise, and face edema.[Ref]

Metabolic

Metabolic side effects have included weight gain, gout, dehydration, and weight loss. FDA warns that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year). Patients who develop hypomagnesemia may experience seizures, dizziness, abnormal or fast heart beat, or skipped heartbeat, jitteriness, jerking movements or tremors, muscle weakness, spasms of the hands and feet, cramps or muscle aches, and spasm of the voice box.[Ref]

Musculoskeletal

Musculoskeletal side effects have included myalgia, arthritis, leg cramps, muscle spasm (tetany) bone pain, bone fracture, arthrosis, bursitis, and rarely rhabdomyolysis. Hip fracture and muscle stiffness have also been reported.[Ref]

An increased risk of hip fracture has been reported. This risk is significantly increased among patients prescribed long-term high dose PPIs.[Ref]
Ocular

Ocular side effects have included cataract, amblyopia, glaucoma, dry eyes, and abnormal vision. Cornea opacity, blurry vision, diplopia, eye pain, and retinal degeneration have been reported rarely. Ocular lesions have also been reported.[Ref]

Psychiatric

Psychiatric side effects have included insomnia, anxiety, depression, nervousness, somnolence, abnormal dreams, decreased libido, agitation, amnesia, confusion, and panic reaction. A least one case of marked anxiety associated with panic attacks, night terror (pavor nocturnus), episodic mental confusion, and attention deficit has been reported.[Ref]

A 55-year-old female with dyspepsia experienced marked anxiety associated with panic attacks, night terror (pavor nocturnus), episodic mental confusion, and attention deficit coincident with rabeprazole therapy. She presented with the neuropsychiatric manifestations 10 days after being administered rabeprazole 20 mg per day. Within two days of discontinuing rabeprazole, she recovered completely.[Ref]

Renal

Renal side effects have included at least one case of interstitial nephritis.[Ref]

A 57-year-old male with diverticulosis, esophageal reflux due to diaphragmatic hernia, and eczema experienced interstitial nephritis coincident with rabeprazole therapy. He was administered rabeprazole 20 mg daily for esophagitis. Renal biopsy revealed interstitial nephritis with unspecified glomerular sclerosis with predominantly interstitial changes. His condition improved when rabeprazole was withdrawn.[Ref]

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Acid reducers linked to kidney disease 5 years 8 months ago #54227

  • mrsb04
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Sandi

References for interstitial nephritis
ndt.oxfordjournals.org/content/19/6/1441.full#ref-list-1.

Omeprazole is the UK equivalent.

I'm a very experienced renal nurse..the first time I came across a PPI causing acute kidney injury was when my 80 year old father developed it after being treated with Omeprazole for about 6 weeks.
Fortunately when a GP checked his routine bloods from a well man check up clinic, he spotted something was amiss and whisked Dad off to hospital. A very lucky escape, caught in time & Dad's kidneys recovered completely.

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Acid reducers linked to kidney disease 5 years 8 months ago #54228

  • Sandi
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  • Sandi Forum Moderator Diagnosed in 1998, currently in remission. Diagnosed with Lupus in 2006. Last Count - 344k - 6-9-18
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Wow - only 6 weeks on the drug! He was very lucky, most do not get blood work often enough to catch problems like that.

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Acid reducers linked to kidney disease 5 years 8 months ago #54229

  • meredithjane
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Sometimes more thorough investigating needs to be done:

My friend's elderly mother has been suffering from reflux & upper abdominal pain for some time.
Last week she was admitted to hospital & her diaphram was found to have stretched, allowing organs, including stomach, to rise into her chest cavity. Her stomach was also twisted. Poor dear. She has had 3 procedures to push her stomach down, untwist it & hold it in place. She also came down with pneumonia in hospital, which thankfully is under control. She has been an active, fun-loving lady, who I consider an extraordinary inspiration. Hoping she will return to our regional town soon.
mj

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Acid reducers linked to kidney disease 5 years 8 months ago #54352

  • Aoi
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Some more info on PPIs and their various risks.
www.medicalnewstoday.com/articles/310080.php
Hope it helps people make informed choices about these drugs.

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