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TOPIC: Autoimmune Disorders Exploding

Autoimmune Disorders Exploding 3 years 9 months ago #53916

  • Melinda
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I found this interesting:


Seasonal Trivalent Influenza Vaccination During Pregnancy and the Incidence of Stillbirth: Population-Based Retrospective Cohort Study

Annette K. Regan1,2, Hannah C. Moore3, Nicholas de Klerk3, Saad B. Omer4,
Geoffrey Shellam1,a, Donna B. Mak2, and Paul V. Effler1,2


+ Author Affiliations
1 School of Pathology and Laboratory Medicine, University of Western Australia, Crawley
2 Disease Control Directorate, Western Australia Department of Health, Shenton Park
3 Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth
4 Global Health and Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia

Correspondence: A. K. Regan, Western Australia Department of Health, PO Box 8172 Perth Business Centre, Perth, Western Australia, 6849, Australia (annette.regan@health.wa.gov.au).

↵a Deceased.


Abstract

Background. Although antenatal influenza vaccination is an important public health intervention for preventing serious infection in pregnant women and newborns, reported vaccine coverage is often <50%. Concern for the safety to the fetus is a commonly cited reason for vaccine hesitancy and refusal. The incidence of stillbirth following pandemic vaccination has been previously studied; however, no population-based study has evaluated the incidence of stillbirth following seasonal trivalent influenza vaccination.

Methods. We used probabilistic linking of perinatal and maternal vaccination records to establish a cohort of 58 008 births occurring between April 2012 and December 2013. Stillbirth was defined as birth ≥20 weeks’ gestation with an Apgar score of zero at 1 and 5 minutes following delivery. Cox regression models adjusted for maternal smoking, Indigenous status, and propensity for vaccination were used to calculate adjusted hazard ratios (aHRs) in vaccinated and unvaccinated mothers.

Results. A total of 5076 (8.8%) pregnant women received trivalent influenza vaccine and 377 stillbirths occurred. There were 5.0 and 3.0 stillbirths per 100 000 pregnancy-days among unvaccinated and vaccinated women, respectively. After adjustment, stillbirth was 51% less likely among vaccinated vs unvaccinated mothers (aHR, 0.49; 95% confidence interval [CI], .29–.84). The largest relative reduction in stillbirths was observed for births occurring just after influenza season (aHR, 0.33; 95% CI, .12–.88).

Conclusions. Mothers who received seasonal TIV during pregnancy were significantly less likely to experience stillbirth compared with unvaccinated mothers. These results support the safety of seasonal influenza immunization during pregnancy and suggest a protective effect.

Key words
stillbirth
seasonal trivalent influenza vaccine
perinatal mortality
maternal immunization

Received October 15, 2015.
Accepted February 5, 2016.

cid.oxfordjournals.org/content/early/2016/03/10/cid.ciw082.abstract




(Sandi I did)

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Autoimmune Disorders Exploding 3 years 9 months ago #53917

  • Sandi
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Oh, I forgot about this. I read about it a few months ago. This girl died of the flu after getting the flu shot.

abcnews.go.com/Health/year-girl-dies-catching-flu-vaccine/story?id=28526729



This girl became paralyzed after the flu shot.

www.youtube.com/watch?v=5VdS0uJPMkU

In each of these cases, parents either feel guilty for something they did, or something they didn't do. It's sad either way. The doctor in one video said that serious reactions are rare. They're not so rare. Of all of the adverse reactions I've seen, ITP is probably one of the most benign problems. I believe that the theory behind vaccines is solid, but the adjuvants are the problem, as stated in many of these studies. The autism rate alone has soared to 1/68 children, and it is estimated that by 2025, 1/2 of the children in the US will be diagnosed with some type of autism. This is a very scary statistic and we need to figure out why. To ignore or refuse to consider the possibility that vaccines may be responsible is negligence. Parents are crying out for help and no one will listen. No one is asking for vaccines to be stopped. They are only asking for more studies regarding safety. I realize that for every argument, there is a counter-argument. I have read many of the counter-arguments and have still come away convinced that there is an issue.

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Autoimmune Disorders Exploding 3 years 9 months ago #53919

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Sandi,

Your latest citations of published research is particularly challenging to the validity of vaccination, at least wrt the flu vaccines; yet, there are at least as many studies which go the other way. The last study you cited gave strong evidence that the 2010-11 vaccine was not very effective, but it is contradicted by parallel studies done for the 2012-13 and 2013-14 flu seasons.
www.ncbi.nlm.nih.gov/pubmed/25416812
www.ncbi.nlm.nih.gov/pubmed/26597255

I was about to write that what is needed is a much larger study, comparing the outcomes of vaccination and non-vaccination on a large scale similar to the Framingham Study, but even the Framingham Study went awry, as incorrect conclusions were drawn from the results for many years.

I do not think that this is just a case of western vs. anti-western medicine. It should be a scientific debate, but there is a justifiable skepticism of scientific studies that may be biased by being funded by the medical industry. Selection bias - (where studies are reported only when favorable to whoever pays for the study, and filed away when unfavorable) - is a very real phenomenon.

I think you are right to focus on the influenza vaccine, as its benefit is not as apparent as with some other vaccines, especially in light of the multiple strains of flu virus that are constantly mutating. By contrast, the Rubella vaccine is 95% effective, and prevents major birth defects that used to result when pregnant women contracted what was then called "German Measles".

When I have disagreed with you on the vaccination issue (or any other) it has always been intended with the same respectfulness that you have always shown when disagreeing with others and myself, for which I am grateful. I pray that you have not confused my disagreement with disrespect, that I haven't contributed to any such confusion, and that you will forgive me if I have.

It will be a sad day when you hand off the reins to another moderator. It would be tragic if you leave feeling disrespected or unvalued, when nothing could be farther from the truth.

You have made an impact on patients of ITP and on this entire area of medicine. Ellen's hematologist has thanked us for teaching her that platelet counts don't have to be normal, and sometimes the best treatment is no treatment at all. We learned that from you, and she from us, and her other patients will benefit from it. And that is just one small example of the difference you have made with your work here.
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Autoimmune Disorders Exploding 3 years 9 months ago #53921

  • Sandi
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As I said, for every argument, there is a counter argument. I've read most of the studies in that link I shared.

The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with the two-vaccine 2009/2010 season. The VAERS database was searched for reports of fetal demise following administration of the influenza vaccine/vaccines to pregnant women. Utilization of an independent surveillance survey and VAERS, two-source capture-recapture analysis estimated the reporting completeness in the 2009/2010 flu season. Capture-recapture demonstrated that the VAERS database captured about 13.2% of the total 1321 (95% confidence interval (CI): 815-2795) estimated reports, yielding an ascertainment-corrected rate of 590 fetal-loss reports per million pregnant women vaccinated (or 1 per 1695). The unadjusted fetal-loss report rates for the three consecutive influenza seasons beginning 2008/2009 were 6.8 (95% CI: 0.1-13.1), 77.8 (95% CI: 66.3-89.4), and 12.6 (95% CI: 7.2-18.0) cases per million pregnant women vaccinated, respectively. The observed reporting bias was too low to explain the magnitude increase in fetal-demise reporting rates in the VAERS database relative to the reported annual trends. Thus, a synergistic fetal toxicity likely resulted from the administration of both the pandemic (A-H1N1) and seasonal influenza vaccines during the 2009/2010 season.

www.ncbi.nlm.nih.gov/pubmed/23023030

Again, I'm not against vaccines. They apparently come with a risk though. If there is even the slightest hint of safety issues, and there is, people need to be aware of it. There is a definite need for more studies. I know the normal drill. You're advised that your arm might be sore for a few days. I had a tetanus shot four years ago and that sucker hurt for days. The problem isn't always immediate reactions. It can be cumulative. Alzheimer's is on the rise. I've read articles that stated that the fluoride in our water binds to the mercury in the vaccines and damages the brain. There is so much more to this than meets the eye. Once you start digging, you keep finding more and you keep digging. That's what happened to me.

I'm not angry and I don't need an apology. I'm sorry you felt that way, Rob. It's just that this subject seems to be taboo and no one wants to discuss it. Hands over ears and la la la la la. I felt like I was made out to be a crack pot. I'm not making this up. This is our health, people. If you decide to keep getting vaccines, great. But if you learn something, that's great too. Never stop questioning. Never stop learning. Science is proven to be wrong all the time, especially medicine. The benefit vs risk assessment should be made for each vaccine. There are very logical reasons to believe that some of them are just not necessary.

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Autoimmune Disorders Exploding 3 years 9 months ago #53923

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“It's just that this subject seems to be taboo and no one wants to discuss it.“
There has been a lot of discussion, and debate back and forth, with citations and everything on both sides.

“Hands over ears and la la la la la.“

There may be those people, but it should be self-evident that they are not the ones who are actively engaged in discussion with you!
There are many who do not want to discuss this, and I can understand why: there are no easy answers. All there is is "argument and counterargument".

There is pretty good proof that vaccines can cause serious problems. But, the question is whether vaccines do more harm than good. Those who would say “yes”, the so-called “anti-vaxers”, typically present the negatives only - as if that is sufficient to prove that vaccines do more harm than good – while ignoring the good that vaccines do.


“I felt like I was made out to be a crack pot. I'm not making this up. This is our health, people. If you decide to keep getting vaccines, great. But if you learn something, that's great too. Never stop questioning. Never stop learning. Science is proven to be wrong all the time, especially medicine.”
It is the ability to be proven wrong which makes science valuable. Medicine is not always scientific. But the only remedy to bad science is more science. (apologies to Justice Brandeis)

“The benefit vs risk assessment should be made for each vaccine. “
I agree 100%.
That assessment is made at the time a drug is approved by the FDA, and is reviewed in light of new information;
bad drugs are removed from the market, but the system is imperfect.


“There are very logical reasons to believe that some of them are just not necessary.”
There are very logical reasons to suspect that some of them are just not necessary.
There are very logical reasons to believe that some of them might not be necessary.
Are there logical reasons to believe (not just suspect) that specific vaccines are not necessary?
Has anyone done the benefit vs. risk assessment that shows this?

Those who sound the alarm raise a lot of good questions, but I have yet to hear one of those questions answered scientifically, in terms of cost vs. benefit.

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Autoimmune Disorders Exploding 3 years 9 months ago #53924

  • Sandi
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The last documentary that I posted discusses risk vs benefit of the whooping cough vaccine. The logic could apply to other vaccines. It's from 1988, but not much has changed since then, other than the addition of many more vaccines. I've watched it twice. It was that interesting.

There are no easy answers. I think that there are many people though who assume that vaccines are just a live or dead virus. They are unaware of the adjuvants and the dangers they pose. We are told that they are safe and just believe that. For me, this isn't about being anti-vaccine. I'm not. It's about wanting safer vaccines and ensuring that the benefit is greater than the risk. There is too much conflicting information out there, and people are being discredited when they shouldn't be. There too, there is more to the story than we hear.

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Autoimmune Disorders Exploding 3 years 9 months ago #53925

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Sandi
I absolutely appreciate the information. I think we all need to question everything we put in our bodies and what we expose them to. I would have no spleen and no understanding of ITP but for this site. I think you are fabulous. I respect you. For whatever all that is worth and I miss you any day I do not see a post from you.
Hugs and much love
Emily
Diagnosed Jan 2015 at age 50 with 13,000.
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Autoimmune Disorders Exploding 3 years 8 months ago #54374

  • Sandi
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Very interesting way to look at it:

truthkings.com/mom-says-giving-child-ingredients-vaccines-moms-threaten-cps/#

Here's the gist. I'm going to try a new supplement with these ingredients:

Medium 199, Minimum Essential Medium, phosphate, recombinant human albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell culture, WI-38 human diploid lung fibroblasts, casamino acids, yeast, ammonium sulfate, Polysorbate 80, succinate buffer, aluminum phosphate, soy peptone broth, 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium, calf serum protein, sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells (DNA from porcine circoviruses), formalin, yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin sulfate, MRC-5 human diploid cells.


These are the listed side effects:

Cancer, diabetes, arthritis, Kawasaki’s disease, blood clotting disorders, encephalitis, Guillian Barre syndrome, rash, death, seizures, brain damage – (but these are probably pretty rare).

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Autoimmune Disorders Exploding 3 years 7 months ago #54638

  • Sandi
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Measles outlook, then (45 years ago) vs now.

www.youtube.com/watch?v=47RUl5xqs_s

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Autoimmune Disorders Exploding 3 years 7 months ago #54639

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I guess most of the 500 deaths per year were not related to healthy, happy affluent suburban kids like the Brady bunch.

www.ncbi.nlm.nih.gov/pubmed/6878996
Rev Infect Dis. 1983 May-Jun;5(3):439-44.
Impact of measles in the United States.
Hinman AR, Orenstein WA, Bloch AB, Bart KJ, Eddins DL, Amler RW, Kirby CD.
Abstract
Measles has had a severe impact on children in the United States since colonial times. In the early decades of the 20th century, thousands of fatal measles infections were reported each year. During the 1950s an annual average of greater than 500,000 cases of measles and nearly 500 deaths due to measles were reported in the United States. Surveys indicated that 95% of the population had been infected with measles by the age of 15 years. The introduction of measles vaccine and its widespread use, which began in 1963, has had a major impact on the occurrence of measles in the United States. Reported numbers of cases, deaths due to measles, and complications of measles (e.g., encephalitis) have declined dramatically. Accompanying the decline in reported incidence of measles and following it by approximately seven years, has been a decline in the reported incidence of subacute sclerosing panencephalitis (SSPE). In recent years, the incidence of measles has dropped to levels that are less than 1% of those seen in the prevaccine era. In 1981, provisional figures indicated that only 10% of counties in the United States reported any cases of measles. The reported incidence in 1981 was 1.3 cases per 100,000 population, compared with an average incidence of 336.3 cases per 100,000 population in the decade 1950-1959. Thus, the impact of measles in the United States has been markedly reduced, and it is anticipated that indigenous transmission will be eliminated entirely from the country within the year.
PMID: 6878996 [PubMed - indexed for MEDLINE]

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Autoimmune Disorders Exploding 3 years 7 months ago #54642

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Sandi wrote: Very interesting way to look at it:

truthkings.com/mom-says-giving-child-ingredients-vaccines-moms-threaten-cps/#

Here's the gist. I'm going to try a new supplement with these ingredients:

Medium 199, Minimum Essential Medium, phosphate, recombinant human albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell culture, WI-38 human diploid lung fibroblasts, casamino acids, yeast, ammonium sulfate, Polysorbate 80, succinate buffer, aluminum phosphate, soy peptone broth, 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, monkey kidney cells, Eagle MEM modified medium, calf serum protein, sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells (DNA from porcine circoviruses), formalin, yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, neomycin sulfate, MRC-5 human diploid cells.


These are the listed side effects:

Cancer, diabetes, arthritis, Kawasaki’s disease, blood clotting disorders, encephalitis, Guillian Barre syndrome, rash, death, seizures, brain damage – (but these are probably pretty rare).


Sigh....I can't stay away. Better to take OTC "natural" supplements where you don't really know what could be in them?

www.wsj.com/articles/oregon-sues-gnc-alleging-supplements-contained-illegal-ingredients-1445543143

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Autoimmune Disorders Exploding 3 years 7 months ago #54752

  • Sandi
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There have been many deaths attributed to the MMR vaccine also. They don't make the news.

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Peer reviewed study - 3 years 7 months ago #54753

  • Sandi
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Twenty years ago it was predicted that a massive increase in immunization would result in a massive increase in people with chronic immune related diseases like type 1 diabetes, autoimmune diseases, and asthma. A massive increase in immunization has occurred. In the United States for example since just 1999 children are scheduled to routinely receive over 80 additional vaccines over their childhood as explained below. The increase in immunization has been followed by a huge increase in inflammation associated disorders.

Diseases like autism, type 1 diabetes, asthma, food allergies, many autoimmune diseases, obesity, type 2 diabetes, NASH and metabolic syndrome have increased many fold in children. The rate of change of several closely followed diseases appear to be accelerating while others have decelerated. This paper describes how the theory of vaccine
induced immune overload can explain many observations about the changes in the epidemics.


www.vaccines.net/vaccine-induced-immune-overload.pdf

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Autoimmune Disorders Exploding 3 years 7 months ago #54754

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Sandi, I think you know me well enough to know I don't put any stock in .com and .net sites for accurate news about health or other things. Yes, the Wall Street Journal is a .com but they do have a reputation for journalistic integrity on their side. I'd rather have you argue WSJ isn't reputable than try to argue with a pdf created by a person or organization who likely has dug in on a particular point of view.

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Autoimmune Disorders Exploding 3 years 7 months ago #54758

  • Sandi
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Okay, but the NIH says the same thing. That's a .gov.

Adjuvants are compounds incorporated into vaccines to enhance immunogenicity and the development of these molecules has become an expanding field of research in the last decades. Adding an adjuvant to a vaccine antigen leads to several advantages, including dose sparing and the induction of a more rapid, broader and strong immune response. Several of these molecules have been approved, including aluminium salts, oil-in-water emulsions (MF59, AS03 and AF03), virosomes and AS04. Adjuvants have recently been implicated in the new syndrome named "ASIA-Autoimmune/inflammatory Syndrome Induced by Adjuvants", which describes an umbrella of clinical conditions including post-vaccination adverse reactions. Recent studies implicate a web of mechanisms in the development of vaccine adjuvant-induced autoimmune diseases, in particular, in those associated with aluminium-based compounds. Fewer and unsystematised data are instead available about other adjuvants, despite recent evidence indicating that vaccines with different adjuvants may also cause specific autoimmune adverse reactions possible towards different pathogenic mechanisms. This topic is of importance as the specific mechanism of action of each single adjuvant may have different effects on the course of different diseases. Herein, we review the current evidence about the mechanism of action of currently employed adjuvants and discuss the mechanisms by which such components may trigger autoimmunity.

www.ncbi.nlm.nih.gov/pubmed/26031899

Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon. Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA. In this perspective we defined four groups of individuals who might be susceptible to develop vaccination-induced ASIA: patients with prior post-vaccination autoimmune phenomena, patients with a medical history of autoimmunity, patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases; asymptomatic carriers of autoantibodies; carrying certain genetic profiles, etc.).

www.ncbi.nlm.nih.gov/pubmed/25277820

In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants' was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other adjuvants, as well as infectious components, that also may have an adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with post-vaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the initiation of breach of tolerance.

www.ncbi.nlm.nih.gov/pubmed/24238833

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Autoimmune Disorders Exploding 3 years 7 months ago #54760

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In my interpretation, they hardly say the same thing. I think that "a massive increase" and "The increase in immunization has been followed by a huge increase in inflammation associated disorders" are saying something very different than "Fortunately, vaccination-related ASIA is uncommon" and "a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena".

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Autoimmune Disorders Exploding 3 years 7 months ago #54765

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We have to be very careful in a discussion such as this one, which I've been reading but not adding to. Some of the claims in the articles above may be committing the "base rate fallacy." When claiming that a certain number of deaths occur after vaccinating or not vaccinating against one or more diseases, it's important to know how many of those deaths would have occurred otherwise. That's the base rate, a number which can be difficult to determine and is often lost in such discussions.

A similar problem is Simpson's paradox ( en.wikipedia.org/wiki/Simpson%27s_paradox ), which can lead to seemingly counterintuitive outcomes in statistical analyses.

My only point here is that extreme caution is required when analyzing data using statistics. Many folks in biomedical research are weak in this area, and the media tends to be virtually ignorant of these issues.

Back to lurking for now.
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Autoimmune Disorders Exploding 3 years 7 months ago #54834

  • Sandi
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The following is a summary of a lecture given by Dr. Darjan Kanduc of the University of Bari, Italy, on the molecular mechanistic functions of vaccine-induced autoimmune disorder:

Since the very beginning of vaccination, people have resisted it due to fear of adverse events. The clash between those resisting vaccination and those promoting vaccination has lasted over 100 years and remains up for debate even today. Nevertheless, adverse health outcomes such as encephalopathy, multiple sclerosis, paralysis, thrombocytopenia, diabetes, sudden infant death syndrome and anaphylaxis, to name just a few, have all come to be associated with vaccination. A common argument used to dismiss such correlations is "correlation does not equal causation." Just because one event follows another does not mean the following event was caused by the preceding event. So the need to explain possible adverse consequences of vaccination at the molecular level has never been greater.

Key to understanding the molecular basis of adverse vaccine events is the influence vaccine components can have on human proteins - molecules critical to the function of living cells. Using proteomics, Dr. Kanduc analyzes the commonality of protein sequences in humans and infectious agents. She takes a protein sequence of an infectious agent by dissecting its primary amino acid sequence into small pieces, and then running them against the database of proteins found in humans.


More at:

info.cmsri.org/the-driven-researcher-blog/vaccine-molecular-mechanisms

Children's Medical Safety Research Institute

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Autoimmune Disorders Exploding 3 years 6 months ago #54899

  • Sandi
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This study was undertaken to evaluate the possible role of hepatitis B recombinant vaccine inducing the synthesis of IgG and IgM anti-cardiolipin antibodies (aCL), antibodies against β2GPI (anti-β2GPI), lupus anti-coagulant (LA), anti-nuclear antibodies and antibodies against extractable nuclear antigens (anti-ENA). The study population consisted of 85 healthy students (63 female, 22 male; mean age 20·8 years), vaccinated with three doses of recombinant DNA hepatitis B vaccine. One month after vaccination with the first dose of hepatitis B vaccine a minority of vaccinated individuals showed changes in IgG or IgM aCL or anti-β2GPI or LA activity (P < 0·001). Among subjects in whom changes of IgG anti-β2GPI were observed, a significantly higher number of increased (8/85) than decreased (2/85) values were found (P < 0·01). Analyses of paired data showed that differences in aCL or anti-β2GPI levels before vaccination or 1 month later did not reach statistical significance. In two people aCL transitorily reached medium positivity after the first dose of hepatitis B vaccine with a drop 5 months later. Similar evident anti-β2GPI fluctuation was also observed in one person. Another participant was initially low positive for IgG anti-β2GPI and the levels were increasing after vaccination. Two participants became positive for anti-nuclear antibodies during 6 months' follow-up. There were no sex-dependent differences in tested antibodies observed and no associations between levels of aPL and levels of anti-HBV antibodies. We conclude that HBV can induce aPL, although rarely. In genetically susceptible individuals or together with some other triggers such combination might confer the risk of developing a continuous autoimmune response in an individual.

www.ncbi.nlm.nih.gov/pmc/articles/PMC1809502/

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Autoimmune Disorders Exploding 3 years 6 months ago #54900

  • Sandi
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Abstract
PURPOSE OF REVIEW:

To present scientific evidence supporting the infectious origin for the antiphospholipid syndrome (APS) by molecular mimicry between pathogens, infection and vaccination with β2-glycoprotein I (β2-GPI) molecule.
RECENT FINDINGS:

APS is characterized by the presence of pathogenic autoantibodies against β2-GPI. The infection etiology of APS was well established. Likewise, a link between vaccination such as tetanus toxoid may trigger antibodies targeting tetanus toxoid and β2-GPI, due to molecular mimicry between the two molecules. During the years, the pathogenic potential of anti-tetanus toxoid antibodies cross reactive with β2-GPI were found to be pathogenic in animal models, inducing experimental APS.
SUMMARY:

Accumulated evidence supports that the presence of anti-β2-GPI antibodies is associated with a history of infections and the main mechanism to explain this correlation is molecular mimicry. The relationship between tetanus toxoid vaccination and APS reveals a novel view on the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA).


www.ncbi.nlm.nih.gov/pubmed/22617823

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Autoimmune Disorders Exploding 3 years 5 months ago #55145

  • Sandi
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Autoimmune Disorders Exploding 3 years 5 months ago #55153

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It makes you wonder: 1st what vaccines contain aluminum and 2nd- does it also cause any type of autism. Just the list he mentioned is very scary. I always ask what is in some of the vaccines I may get, but the nurse never tells me the truth! I just got a tetnus shot and wasn't told the truth.

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Autoimmune Disorders Exploding 3 years 5 months ago #55156

  • Melinda
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www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/aluminum#.V501P8uFMkI
"Aluminum adjuvants are used in vaccines such as hepatitis A, hepatitis B, diphtheria-tetanus-containing vaccines, Haemophilus influenzae type b, and pneumococcal vaccines, but they are not used in the live, viral vaccines, such as measles, mumps, rubella, varicella and rotavirus.

Vaccines containing adjuvants are tested extensively in clinical trials before being licensed. Aluminum salts and a detoxified bacterial component called monophosphoryl lipid A are the only materials that can be used as adjuvants in the United States. The quantities of aluminum present in vaccines are low and are regulated by the Center for Biologics Evaluation and Research (CBER)."


Isn't it an MMR that everyone swears causes autism? Well aluminum isn't in it according to the Children's Hospital of Philadelphia.

DeeDee is it possible that nurses do not know every ingredient in every vaccine? did she really lie to you or did she just not know. Was she an RN, LPN, assistant or what?

I am not going to watch the video - can't tell who is talking or where it is from.

But I do feel that for every negative post someone submits they need to also submit the side effects of the diseases.

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Autoimmune Disorders Exploding 3 years 5 months ago #55157

  • Melinda
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I don't know how to put a link in so that the video is right in the post as Sandi can do.

But please do click on the link and watch this video from Children's Hospital of Philadelphia:
Is the Aluminum in Vaccines Safe?


www.chop.edu/centers-programs/vaccine-education-center/video/aluminum-vaccines-safe#.V503UsuFMkI

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Autoimmune Disorders Exploding 3 years 5 months ago #55160

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Melinda,

I had asked the nurse if I had to have the combination vaccine (I think it is called DTap)--also
for whooping cough. She said this is the only way it comes. Later, I found out I could have had it
done at Walmart (Just the tetanus by itself). I didn't feel good after the vaccine for over a week. It did make me sick. And, I was worried about my platelets. Our bird had bit and broke my knuckle and it looked
really bad--so I did need the tetanus. I had actually called before I went in--but didn't call Walmart.

The vaccines scare me because the last time my platelets were really low, I had about three vaccines at once, and they immediately dropped even lower to about 10,000. I'm allergic to something in the vaccines and my one friend told me to make sure not to get any live vaccine (I think they have mercury?).

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Autoimmune Disorders Exploding 3 years 5 months ago #55161

  • Melinda
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www.cdc.gov/vaccinesafety/Concerns/thimerosal/index.html?s_cid=cs_748

DeeDee was this an RN, LPN, assistant or what?

I'll tell you - a tetanus booster took me out of "remission" [counts 85k-125k for years], count tanked I refused prednisone and ended up with a WinRho IV and so far so good. I've always been told as someone with ITP I shouldn't get a live vaccine - but because it was live.

Did you happen to watch the video I posted?

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Autoimmune Disorders Exploding 3 years 5 months ago #55169

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Not yet, Melinda, but I will!! I, too, am very afraid of vaccines. If it wasn't for my finder being infected, I sure wouldn't have gotten it!

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Autoimmune Disorders Exploding 3 years 5 months ago #55239

  • Sandi
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DeeDee:

Every vaccine has a list of ingredients that comes with the vaccine vial. It is your right to see it, as well as the insert with the list of potential side effects. They don't like to give that out and you'd need a magnifying glass to see it. Those lists are also on the CDC website. There have been very little testing or studies done on the adjuvants. From what I have read, when they do test vaccines, they have two test groups. One gets the vaccine and the other group gets the adjuvants. They compare those two groups and deem them comparable.

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Autoimmune Disorders Exploding 3 years 5 months ago #55240

  • Sandi
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Physicians are often puzzled by patients who suffer from a complex array of signs and symptoms that cannot easily be categorized into a single defined autoimmune or autoinflammatory disease. Such enigmatic conditions, although common in clinical practice, are rarely reported in the medical literature because they are so diverse and often present with nonspecific and vague findings. Not surprisingly, their pathogenesis remains a mystery. Moreover, possible therapies for these patients are difficult–if not impossible–to evaluate because most clinical trials are designed to follow patients with well-defined diseases and involve validated outcomes that often include specific markers.

As an example of such a complicated and perplexing situation, consider the following recently published case.1 The report described a 56-year-old woman diagnosed with chronic fatigue, fibromyalgia, weakness, headaches, difficulties concentrating, short-term memory impairment, and evidence of a demyelinating illness. Laboratory testing indicated the presence of high levels of antiadrenal, antistriated muscle, and antismooth muscle antibodies; increased rheumatoid factor titers; and elevated immunoglobin (Ig) G, IgM, and IgA immune complexes. The patient’s illness had begun 13 years earlier following the second dose of hepatitis B vaccine and was aggravated by the third vaccination. In addition, several years before vaccination, the patient had undergone uneventful silicone breast implantation. However, during the time between her second and third vaccination, she suffered a breast injury accompanied by evidence of local inflammation. Four years afterwards, she underwent removal of her breast implants. On histological examination, leaking of silicone and extensive calcification in both breasts was observed. In addition to removal of the implants, the patient was treated with intravenous IgG, and her condition gradually improved.

This illustrative case is notable for several clues that suggest a possible role of exposure to the hepatitis B vaccine and silicone leak that, together, produced an augmented adjuvant effect and led to the patient’s condition. In recent years, a large body of evidence has accumulated on the basis for vague conditions such as chronic fatigue and sick building syndromes. Subsequently, other poorly defined (and sometimes controversial) conditions—for example, siliconosis (relating to manifestations occurring following exposure to silicone) and postvaccination phenomena such as Gulf War syndrome (GWS) and the macrophagic myofasciitis syndromes (MMF)—have been suggested to have a common pathogenesis.

Because these enigmatic diseases can display similarities in the presenting complex of signs and symptoms, a shared etiological common denominator is possible. In addition, accumulating data regarding immune adjuvant activity stimulated by various substances (e.g., infectious agents, silicone, aluminum salts) have been associated with the pathogenesis of each of these conditions. Thus, their comparable clinical presentation and plausible common mechanisms have led to the convergence of these conditions under a common syndrome called autoimmune (autoinflammatory) syndrome induced by adjuvants (ASIA).

The worldwide prevalence of autoimmune and autoinflammatory diseases is determined by the interplay of genetic and environmental factors.7 The latter factors include infections, toxins, drugs, and others agents that can be linked by the occurrence of immune-mediated diseases as well as the nature of the clinical manifestations and their severity.8,9 The mechanisms by which these environmental factors trigger autoimmunity are diverse but, as a group, they may incorporate an adjuvant effect. An adjuvant is a substance that enhances the activation of the immune system, both the innate and the adoptive ones.


www.the-rheumatologist.org/article/asia-a-new-way-to-put-the-puzzle-together/

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Autoimmune Disorders Exploding 3 years 5 months ago #55241

  • Sandi
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These are the ingredients in the MMR vaccine.

MMR II
Medium 199 (vitamins, amino acids, fetal bovine serum, sucrose,
glutamate) , Minimum Essential Medium, phosphate, recombinant human
albumin, neomycin, sorbitol, hydrolyzed gelatin, chick embryo cell
culture, WI-38 human diploid lung fibroblasts

MMRV (ProQuad)
sucrose, hydrolyzed gelatin, sorbitol, monosodium L-glutamate, sodium
phosphate dibasic, human albumin, sodium bicarbonate, potassium
phosphate monobasic, potassium chloride, potassium phosphate dibasic,
neomycin, bovine calf serum, chick embryo cell culture, WI-38 human
diploid lung fibroblasts, MRC-5 cells

www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf

This page breaks down the ingredients one by one:

www.globalhealingcenter.com/natural-health/what-are-the-dangers-of-the-mmr-vaccine/

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