I'm curious what numbers people have experienced on promacta. I'm currently doing 50mg per day and am at ~200 which I know is a bit high. But over the winter I dropped to 25mg per day and eventually crashed and required a dex pulse, so I'm iffy to reduce the dose.
Diagnosis of ITP in 2014. Ex renal specialist nurse. I retired in Nov 2019 after 46 years on the front line. I firmly believe in empowering patients to be involved as much as possible in their care; always question medics about the evidence base they use.
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Personally I would try 25mg/50mg on alternate days. In the UK our guidelines are reduce the dose if a count is over 150. I get twitchy if mine goes to the high 90s
lurpelis wrote: I'm curious what numbers people have experienced on promacta. I'm currently doing 50mg per day and am at ~200 which I know is a bit high. But over the winter I dropped to 25mg per day and eventually crashed and required a dex pulse, so I'm iffy to reduce the dose.
Is 200 too high and too much of a risk of clots?
If one carry's Aspirin in their back pocket to take at a moments notice, probably ok to have 200+ count.
Perhaps you had a bit of Flu last winter to cause the platelet crash then. In that case going to 25 now isn't much of a risk. Can just take 50mg for awhile if counts crash when this winter's Flu season comes around. How is your vitamin and Folate consumption?
To answer your question. 25mg gives me about 135. 50mg was putting me on a trajectory higher than 200 so never got there. Likely would have been around 270. Dose and count proportionality are closely linked in my case. And so goes a response like this when one seems to have antibodies against circulating TPO. Lots of sensitivity to TPO-RA drugs.
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