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TOPIC: New ITP drug???

New ITP drug??? 4 months 2 weeks ago #66910

  • Carcamoc10
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Is anyone familiar with Doptelet (avatrombopag) ? I saw it was just approved for chronic ITP but I have yet to hear about it...thoughts anyone?

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New ITP drug??? 4 months 1 week ago #66913

  • mrsb04
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New ITP drug??? 4 months 1 week ago #66914

  • MelA
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If you get the PDSA e-News it came in my email overnight and there is an article in there about it
"Instead of wasting your time worrying about symptoms, just get it checked out" -Nieca Goldberg, MD

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New ITP drug??? 4 months 1 week ago #66918

  • Carcamoc10
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Mrsb04 thanks for the article, it was a lot more detailed than the one they had in the news section of the home page!! It sounds promising, I think...I’ll have to bring it up to my hemo next appointment!!

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New ITP drug??? 3 months 3 weeks ago #67064

  • ccurley
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I just received my first months supply. I wont start until August 1st. Excited to try. I am on Tavallese daily and Nplate once a week. Will stop Nplate and start Doptelet.
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New ITP drug??? 3 months 3 weeks ago #67065

  • Carcamoc10
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Ccurley, be sure to let us know how it goes!! & just out of curiosity: What do the Tavalisse and NPlate keep your platelets at, usually?

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New ITP drug??? 3 months 3 weeks ago #67070

  • ccurley
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Between 14 and 49 (49 highest and only once in a year or so). Dr said I will stop Nplate when I start Doptelet works on same receptors? I want to stop Tavallese though, diarrhea side effects for over a year, annoying.

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New ITP drug??? 3 months 3 weeks ago #67080

  • poseymint
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Thanks Ccurley for sharing your information about this new drug. It seems similar to Promacta but can be taken with food and doesn't have the risk of liver toxicity so they are marketing it to patients with chronic liver disease that also have low platelets. And to ITP patients. Good to have more choices! The cost is a bit shocking- I am seeing it costs nearly $10,000. for 10 pills- whoa. The only good thing about that is that my hematologist had been irritated in the past that I am on the expensive drug Nplate without having a failed splenectomy first. These new drugs like Tavlisse and Avatrombopag are great in that they make Nplate look cheap. Anyway, hope it works for you!

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New ITP drug??? 3 months 3 weeks ago #67081

  • mrsb04
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My understanding is that Doptelet is licensed for patients with chronic liver disease who have ITP and need a platelet increase pre surgery and for short term use only

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New ITP drug??? 3 months 2 weeks ago #67131

  • ccurley
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New ITP drug??? 3 months 2 weeks ago #67132

  • ccurley
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Poseymint, hello I was on the study for Eltrombopag/Promacta in Baltimore back in early 2000s and it worked. I was then put on Promacta and unfortunately I turned yellow and numbers went thru the roof. I stopped and back to normal, so I am excited about this Avatrombopag and no risk of liver toxicity, we shall see. I had a $70 co pay and just received a call and a phone number to call pharmaceutical company regarding the copay, calling them today. My hematologist will bring up spleenectomy every now and again and I am not interested. When I was about 12 years old the doctor then suggested and my Mom said no. So 50 years later and it's still no :) As I am older now I certainly don't want to compromise my immune system and only 50% chance it will work.
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New ITP drug??? 2 months 5 days ago #67458

  • ccurley
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Hello! Still taking Avatrombopag or Doptelet. I started with one 20mg a day and ended Nplate. After 2 weeks my platelets dropped to 22 from 33. So I increased to 40mg a day. It has been 3 weeks and platelets slowly increased to 39 and all other blood work is normal. Going to every 2 weeks for blood work, hallelujah. If I remain steady or increase hopefully will be able to go down to one Tavalisse a day and perhaps get rid of them altogether. So that's the story so far. Will post in a few weeks after I see how labs play out. Take care.

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New ITP drug??? 2 months 5 days ago #67459

  • Carcamoc10
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Ccurley I’m glad things are going well, thank you for the update :)

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