Be a part of the ITP community and stay informed.
Login to your account or REGISTER
.

•  Web site Help & Info

Welcome, Guest
Username: Password: Remember me
  • Page:
  • 1

TOPIC:

Rituxin during Covid 8 months 2 days ago #72109

  • russp
  • Offline
  • Posts: 30
  • Thank you received: 2
So, been in remission for nearly 5 years now (thanks Rituxin). I've had Rituxin three times now during the past 9 years.. It's looking like my platelets are getting low now (waiting on Quest test to confirm). Anyways besides being concerned that the Pfizer vaccine is the cause (not like I probably would have not gotten anyways, but still....) I was wondering if any of you have done a round of Rituxin during Covid? I read a study that said Rituxin gave about a 1.72 mutliplier to risk of bad Covid results but that included a lot of cancer patients too so guessing maybe more like 1.4 multiplier for ITP patients? Dunno. Anyways, still maybe a concern about going onto Rituxin while Omicron is raging.  Just curious if anyone had a hemo say anything about Covid and Rituxin during the pandemic and what they said.

Also anyone know if after 6 months Rituxin is fully gone from your system and hence no longer a Covid risk multiplier? I'm guessing 6 months simply because I think that's about how often the poor Rheumatoid arthritis suffers get it so figure maybe it wears off in 6 months.  

Id be grateful for anything anyone has heard as trying to formulate a plan of what I'll do if my count is as low as I suspect.

Please Log in or Create an account to join the conversation.

Rituxin during Covid 8 months 6 hours ago #72112

  • JJ
  • Offline
  • Posts: 219
  • Thank you received: 75
Six months would be quick for ritux effects to go. More like 9 to 12 months. I've had ritux for lymphoma recently. Had an antibody test after the vaccine and it was negative but as you've already been vaccinated you won't be in quite the same situation. If it were me, I'd look to do a different treatment but then I've always felt that ritux for ITP is rather like using a hammer to crack a nut.

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 4 weeks ago #72123

  • russp
  • Offline
  • Posts: 30
  • Thank you received: 2
Yeah, I might have to go for the spleen removal finally.  Reading more it seems Rituxin (in any dosage) kill all your b-cells for 9 to 12 months usually which is scary given they are important in Covid recovery and antibody production memory.  I go tomorrow and will ask about the spleenectomy as he has suggested it multiple times.  I respond well to Rituxin and Prednisone so from what I've read that seems to be one indicator of higher chance of the spleenectomy being a success.  I just wonder what medications are involved in it and likely recover. I've heard many say it's not a big deal done laprascopically and did not impact their life really living without it but still....

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 4 weeks ago #72125

  • gozorakgogo
  • Offline
  • Posts: 133
  • Thank you received: 17
My own experience with Rituxin came when I was administered 4 weekly dosages in july/aug 2020 after I was stricken with ITP out of the blue for the first time putting me in the hospital and ICU with a platelet count of 2 for 10 days. After only minimal improvements using prednisone as well as the temporary platelet increases by way of IVIG and platelet transfusions it was decided to opt for Ritux infusions and Nplate injections.
This all occurred within the first 5 months of the pandemic hitting here in the US. At no point was it ever emphasized to me that Ritux would increase my risk of a bad Covid infection(Im suspicious that it may have been a Covid infection that actually triggered ITP but have no way of knowing) In fact, Covid was never mentioned or brought up in any way in regards to the reason I was in the hospital or potential effects of the therapies administered. I work in the public. I was out of work for 5 weeks after my final Ritux infusion. Needless to say I went back to work and made it through the entire time as my immune system reconstituted itself without getting covid. I got my first Pfizer injection(3 times vaxxed now) about 7 months after that final Ritux treatment with no issues. Nor were there any issues after my other two covid jabs.

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 4 weeks ago #72132

  • CindyL
  • Away
  • Posts: 1482
  • Karma: 1
  • Thank you received: 211
Hi, russ.  I was diagnosed with ITP in 2004 and had my spleen out in 2006.  It worked for about a month.  You're right, most people do live fine with out it; I do.  But I do avoid anyone who I know has a cold and with this Covid I'm extra careful.  I was told that at the first sign of a fever, I should go to the hospital or my doctor, but I don't do that.
I did Rituxan in 2011 and my counts started going up with the first treatment.  My counts improved so much, I was surprised when I did the last dose. I have had normal numbers since.
Good luck with whatever you choose.
The following user(s) said Thank You: russp

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 4 weeks ago #72135

  • russp
  • Offline
  • Posts: 30
  • Thank you received: 2
Thanks everyone for the responses. Hemo this morning convinced me to do Rituxin given it has worked so well for me. He also said, "yeah, i'd keep my spleen as long as you can".   Their hemo practice has not taken one out for many years and it's a pretty big practice here in North Atlanta area.

Also, he said that they are not really seeing any significant adverse outcomes for Covid for all the people on Rituxin of which they have many since of course it's a cancer center. Prednisone has me up to 57 for today so continue with that until get Rituxin scheduled.  

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 3 weeks ago #72142

  • Rob16
  • Offline
  • Posts: 1125
  • Karma: 2
  • Thank you received: 275
"Prior treatment with [Rituxan] likely renders COVID-19 vaccine ineffective, study finds
"Rituximab, a drug widely used in patients with lymphoma, blunts or eliminates the antibody response to COVID-19 vaccines if it is administered before them, Stanford researchers say."
med.stanford.edu/news/all-news/2022/02/rituximab-treatment-covid-19-mrna-vaccines.html

However, vaccinating first is effective . (same study)
"Comparing patients who received anti-CD20 treatment before or after vaccination, we demonstrate that vaccinating first can generate an antibody response that endures through anti-CD20–containing treatment."
bloodcancerdiscov.aacrjournals.org/content/early/2022/01/29/2643-3230.BCD-21-0222-0

Please Log in or Create an account to join the conversation.

Rituxin during Covid 7 months 3 weeks ago #72143

  • russp
  • Offline
  • Posts: 30
  • Thank you received: 2
Correct.  If you vaccinate after getting Rituxin it mostly voids it due to lack of b-cells.  I'm tripled vaxed for nearly 2 months now so should be good to go.  Dunno when they will schedule me as he just barely put me on the Prednisone to get the count up (it's up) but I expect very soon.

Please Log in or Create an account to join the conversation.

  • Page:
  • 1

Charity NavigatorGuideStar Seal NORD Member BadgeTHSNA logo