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New guidelines 2 years 1 month ago #68040

  • JJ
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New guidelines 2 years 1 month ago #68041

  • JJ
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  • Posts: 190
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Most interesting thing in these guidelines for me is the way the advised use of steroids has changed. They now say to start reducing the dose after two or three weeks and aim to be off them completely in six weeks. That sounds wonderful compared with what many of us went through.

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New guidelines 2 years 1 month ago #68042

  • mrsb04
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  • Diagnosis of ITP in 2014. Retired (Nov 2019) renal specialist nurse, 46 years on the NHS front line. My belief is empower patients to be involved as much as possible in their care. Read, read, read & ALWAYS question medics about the evidence base they use
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JJ
Sounds absolute heaven. 5 years I've had ITP and still tapering. Down to 1mg/day now.
Very comprehensive guidelines, well referenced and well presented.

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New guidelines 2 years 1 month ago #68069

  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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Oh that was quick. They were talking about how it may take a long time for everyone to agree to it at the PDSA conference this summer. Guess their wasn't much disagreement.

Need to read through the whole thing. On skimming, I'm a little disappointed they didn't go into detail about why a TPO diagnostic test is, or is not, helpful. As I recall from the relevant study, TPO level predicts TPO-RA dosage - which aligns with my ITP treatments table. Maybe I missed it in the document.

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New guidelines 2 years 1 month ago #68163

  • NK18
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Hi Hal9000, they were saying that steroids need to be removed, if I recall correctly. Or given just for 2 weeks.

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New guidelines 2 years 4 weeks ago #68219

  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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Not sure NK. I don't respond to steroids so details about steroids seems to go in one ear and out the other quite easily. What I recall is a desire for treatment protocol being able to go from steroids directly to Promacta/Nplate. That does seem to be in there.

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New guidelines 2 years 4 weeks ago #68220

  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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Had the opportunity to read the whole thing. A few things came to mind.

- Noting that
"vitamin B12 and Folate deficiency can result in thrombocytopenia"
is useful and enlightening

- No discussion on Promacta doses greater than 75mg (new for 2019?)

- This footnote referenced sentence:
"a prospective case-control study found no increased incidence of ITP following vaccination (evidence level IIb)"
contradicts the rest of the paragraph on "Testing for other acute and persistent infections"

- No mention that TPO level is a cursory predictor of TPO-RA dose. This information would allow skipping to higher Nplate doses when appropriate. Low TPO level indicates low TPO-RA dose. Normal level indicates medium dose. High level indicates high dose required.

- On IVIG studies:
"Two have found a reduced IVIg response in patients with only anti–GPIb-IX antibodies."
Well, that's a good start. How about studying those that achieve remission via TPO-RA treatment only? That they are the folks who have poor IVIG responses.

- This assertion on children, I think from what I've seen around here, is true for adults as well:
"Two studies have indicated that response to rituximab is correlated with steroid response (P = .002) (evidence level IIb)"

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