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Platelet antibody 2 years 7 months ago #66701

  • Angelito0130
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Hello, 16 month old daughter was diagnosed with ITP on March 4th, a few days ago her hematology did PLATELET ANTIBODY, DIRECT (IGG)
Plt Associated Anti-IIB/III positive Plt Associated Anti-IB/IX positive
Plt Associated Anti-IA/IIANegative
Do you guys have any clue about the meaning of the reults?
Thank you

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Platelet antibody 2 years 7 months ago #66717

  • lurpelis
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These are tests for antibodies against molecules which are known to be potentially on platelets. The positive antibodies test could indicate autoimmune activity against platelets. As of now I do not believe positive or negative platelet antibody tests alter course of treatment, but help to confirm ITP.
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Platelet antibody 2 years 7 months ago #66718

  • Angelito0130
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Before the results, her hemo wants to do a bone marrow biopsy, but after the results I hope doctor change his mind about doing a biopsy!!!

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Platelet antibody 2 years 7 months ago #66719

  • Hal9000
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  • Give me all your platelets and nobody gets hurt
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Angelito, the immune system is very complex. Those 3 tests identify which antibody groups are potentially attacking platelets. There is a lot of good general information on Wikipedia:
... "Most often these antibodies are against platelet membrane glycoproteins IIb-IIIa or Ib-IX, and are of the immunoglobulin G (IgG) type." ...
en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura

I suspect that your doctor was trying to eliminate familial/congenital Thrombocytopenia as a possible diagnosis. One would expect all three to be negative in that situation. See the end of this study's abstract:
"Prospective evaluation of a new platelet glycoprotein (GP)-specific assay (PakAuto) in the diagnosis of autoimmune thrombocytopenia (AITP)"
www.ncbi.nlm.nih.gov/pubmed/15726595
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Platelet antibody 2 years 7 months ago #66730

  • lurpelis
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Bone marrow biopsy is a very common approach to ITP diagnosis, it's to ensure there is no other cause like cancer or a different rare blood condition. I had one done and it is minimally invasive and I recovered quickly and with little to no pain.

Though it sounds scary, it's arguably one of the best tools to make sure they diagnose your daughter correctly.
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