Mononucleosis, aka EBV, like other Herpes viruses is life long. These viruses are known to hitch a ride on platelets to spread and this behavior leads to ITP.
"Platelets and Infection – An Emerging Role of Platelets in Viral Infection"
Is it a coincidence that chronic ITP is only chronic because Herpes viruses cannot be eradicated from the body?
On a slightly different note, about the article on Platelets and Infection. Besides the Herpes viruses, the Influenza virus is implicated too. But the Flu virus CAN be eradicated from the body. So are 'spontaneous' ITP remissions
(row 2 on my ITP table)
only because those folks had ITP triggered by the Flu? Once the Flu virus went away, so did the ITP, once the immune system settled down?
Further. As we know, children's immune system must learn how to destroy lots of invaders as we grow up. Flu viruses are always changing. As new strains come along, some are brand new to a child - offering a big challenge to the immune system. What if most cases (80%) of ITP in children can be attributed to the Flu? Is that the reason why most cases of ITP in children self resolve?
Even further. Is it possible that this study, which seems to accurately predict acute versus chronic ITP doing nothing more than identifying those children who had ITP triggered by the Flu (and are thus row 2 in my table)?
"Expression Differences Distinguish Pediatric Acute and Chronic ITP Using RNA Sequencing"
Diagnosed in 2000, at 59, after being on moderately high doses of NSAIDs for arthritis. Splenectomy and rituxan both failed (2004). Did well on prednisone till summer 2018--then terrible reactions. Promacta since 11-19.
Thank you received: 51
I note that this article was published in June of 2016. Do you know if there has been response to it?
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