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I wonder whether this sources of ITP is unresponsive to treatments other than splenectomy, such as Rituxan.[...] antibody AN51 [...] induced [...] clustering that led to [...] platelet aggregation. [...] and the platelets were mainly removed by macrophages in the liver.
This chemical has been shown to be effective in suppressing autoimmune attacks in multiple sclerosis:N-acetyl-D-glucosamine, previously shown to inhibit integrin αMβ2 mediated phagocytosis of refrigerated platelets, dose-dependently inhibited AN51-induced platelet clearance.
www.sciencedaily.com/releases/2011/09/110930123057.htm
Glucosamine-like supplement suppresses multiple sclerosis attacks, study suggests
Date: September 30, 2011
Source: University of California - Irvine
Summary: A glucosamine-like dietary supplement suppresses the damaging autoimmune response seen in multiple sclerosis, according to a new study.
The study comes on the heels of others showing the potential of GlcNAc in humans. One reported that eight of 12 children with treatment-resistant autoimmune inflammatory bowel disease improved significantly after two years of GlcNAc therapy. No serious adverse side effects were noted.
"Together, these findings identify metabolic therapy using dietary supplements such as GlcNAc as a possible treatment for autoimmune diseases," said Demetriou, associate director of UCI's Multiple Sclerosis Research Center. "Excitement about this strategy stems from the novel mechanism for affecting T-cell function and autoimmunity -- the targeting of a molecular defect promoting disease -- and its availability and simplicity."
He cautioned that more human studies are required to assess the full potential of the approach. GlcNAc supplements are available over the counter and differ from commercially popular glucosamine. People who purchase GlcNAc should consult with their doctors before use.
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