lisaknaack, though I myself have not experienced a loss of response, from reading posts here, loss of response to a particular ITP drug appears to happen fairly often. Since there are 4 known antibodies which can possibly contribute to ITP, it is a plausible projection that the situation might be that he has gone from one bad antibody to two bad antibodies contributing to lower counts.
Having said that, it is also quite possible to just experience a change in response that can be compensated for by merely increasing the dose, the dose of Nplate in this case. Nplate doses are normally expressed as an integer from 1 to 10 and represent the amount of the drug divided by one's weight in kg. For example, a '5' dose would be half the max dose of '10'. So, perhaps just an increase in dose was required here, yes?
On a covid19 side note. As I understand, one can get an ongoing idea of its active presence from a full/complete blood count test, aka CBC - which occur all the time with ITP. Covid19 causes out of range low red blood cell count (RBC), with normal RBC morphology, and an out of range Hemoglobin, either out of range high or out of range low. If white blood cells eventually fall through the floor, then that would be a very, very bad indication.
How is he doing?
